PRKAA1
Summary: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase AMP-activated catalytic subunit alpha 1 | MIM:602739 | Ensembl:ENSG00000132356 | HGNC:HGNC:9376 | PA33744 | 5p13.1 |
GO terms in PRKAA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003682 | chromatin binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004679 | AMP-activated protein kinase activity |
| MF | ISS | GO:0004679 | AMP-activated protein kinase activity |
| MF | TAS | GO:0004679 | AMP-activated protein kinase activity |
| MF | NAS | GO:0004691 | cAMP-dependent protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | ISS | GO:0035174 | histone serine kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0047322 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity |
| MF | IEA | GO:0050321 | tau-protein kinase activity |
| MF | IEA | GO:0050405 | [acetyl-CoA carboxylase] kinase activity |
| CC | IMP | GO:0005622 | intracellular |
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IBA | GO:0031588 | nucleotide-activated protein kinase complex |
| CC | ISS | GO:0031588 | nucleotide-activated protein kinase complex |
| CC | TAS | GO:0031588 | nucleotide-activated protein kinase complex |
| CC | ISS | GO:0043025 | neuronal cell body |
| BP | NAS | GO:0000187 | activation of MAPK activity |
| BP | NAS | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006633 | fatty acid biosynthetic process |
| BP | IEA | GO:0006695 | cholesterol biosynthetic process |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0008610 | lipid biosynthetic process |
| BP | IEA | GO:0009411 | response to UV |
| BP | IEA | GO:0009631 | cold acclimation |
| BP | ISS | GO:0010332 | response to gamma radiation |
| BP | IDA | GO:0010508 | positive regulation of autophagy |
| BP | IMP | GO:0010508 | positive regulation of autophagy |
| BP | ISS | GO:0010508 | positive regulation of autophagy |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0014823 | response to activity |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | IEA | GO:0019395 | fatty acid oxidation |
| BP | IEA | GO:0031000 | response to caffeine |
| BP | ISS | GO:0031669 | cellular response to nutrient levels |
| BP | IBA | GO:0032007 | negative regulation of TOR signaling |
| BP | ISS | GO:0032007 | negative regulation of TOR signaling |
| BP | IEA | GO:0033135 | regulation of peptidyl-serine phosphorylation |
| BP | ISS | GO:0034599 | cellular response to oxidative stress |
| BP | IEA | GO:0035404 | histone-serine phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0042149 | cellular response to glucose starvation |
| BP | ISS | GO:0042149 | cellular response to glucose starvation |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | ISS | GO:0043066 | negative regulation of apoptotic process |
| BP | NAS | GO:0045542 | positive regulation of cholesterol biosynthetic process |
| BP | ISS | GO:0045821 | positive regulation of glycolytic process |
| BP | NAS | GO:0046318 | negative regulation of glucosylceramide biosynthetic process |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | IEA | GO:0048643 | positive regulation of skeletal muscle tissue development |
| BP | ISS | GO:0050995 | negative regulation of lipid catabolic process |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | ISS | GO:0055089 | fatty acid homeostasis |
| BP | IEA | GO:0060627 | regulation of vesicle-mediated transport |
| BP | IGI | GO:0061744 | motor behavior |
| BP | IC | GO:0061762 | CAMKK-AMPK signaling cascade |
| BP | IMP | GO:0061762 | CAMKK-AMPK signaling cascade |
| BP | TAS | GO:0061762 | CAMKK-AMPK signaling cascade |
| BP | IGI | GO:0070050 | neuron cellular homeostasis |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | ISS | GO:0070507 | regulation of microtubule cytoskeleton organization |
| BP | ISS | GO:0071277 | cellular response to calcium ion |
| BP | ISS | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071361 | cellular response to ethanol |
| BP | IEA | GO:0071380 | cellular response to prostaglandin E stimulus |
| BP | IEA | GO:0071417 | cellular response to organonitrogen compound |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | ISS | GO:0097009 | energy homeostasis |
| BP | TAS | GO:0097009 | energy homeostasis |
| BP | IEA | GO:1901563 | response to camptothecin |
| BP | IEA | GO:1903109 | positive regulation of mitochondrial transcription |
| BP | ISS | GO:1903829 | positive regulation of cellular protein localization |
| BP | IEA | GO:1903955 | positive regulation of protein targeting to mitochondrion |
| BP | ISS | GO:1904428 | negative regulation of tubulin deacetylation |
| BP | ISS | GO:2000758 | positive regulation of peptidyl-lysine acetylation |
| BP | IEA | GO:2001274 | negative regulation of glucose import in response to insulin stimulus |
Gene expression in normal tissue: PRKAA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKAA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | leptinpathway | reversal of insulin resistance by leptin |
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Leptin | Leptin |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2011 | SREBF and miR33 in cholesterol and lipid homeostasis |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP3595 | mir-124 predicted interactions with cell cycle and differentiation |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3934 | Leptin and adiponectin |
| wikipathways | WP3965 | Lipid Metabolism Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4206 | Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway |
| wikipathways | WP481 | Insulin Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD630 | ML203 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD221 | Tamoxifen | 6 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKAA1
CLASSFICATION
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