PRKCB
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:176970 Ensembl IDEnsembl:ENSG00000166501 HGNC IDHGNC:HGNC:9395 PHARMGKB IDPA33761 Map Location16p12.2-p12.1 | |||||
GO terms in PRKCB
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
Gene expression in normal tissue: PRKCB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCB
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | endothelinpathway | Endothelins |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCB
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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