PRKCB
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C beta | MIM:176970 | Ensembl:ENSG00000166501 | HGNC:HGNC:9395 | PA33761 | 16p12.2-p12.1 |
GO terms in PRKCB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
| BP | NAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0010829 | negative regulation of glucose transmembrane transport |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | ISS | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | IDA | GO:0035408 | histone H3-T6 phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0042113 | B cell activation |
| BP | TAS | GO:0042953 | lipoprotein transport |
| BP | ISS | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0045637 | regulation of myeloid cell differentiation |
| BP | ISS | GO:0045766 | positive regulation of angiogenesis |
| BP | ISS | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | ISS | GO:0050853 | B cell receptor signaling pathway |
| BP | ISS | GO:0050861 | positive regulation of B cell receptor signaling pathway |
| BP | ISS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004697 | protein kinase C activity |
| MF | TAS | GO:0004698 | calcium-dependent protein kinase C activity |
| MF | IPI | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IMP | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0035403 | histone kinase activity (H3-T6 specific) |
| MF | IDA | GO:0042393 | histone binding |
| MF | IDA | GO:0050681 | androgen receptor binding |
Gene expression in normal tissue: PRKCB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | endothelinpathway | Endothelins |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
| pid | tcrraspathway | Ras signaling in the CD4+ TCR pathway |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Wnt | Wnt |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3944 | Serotonin and anxiety-related events |
| wikipathways | WP3947 | Serotonin and anxiety |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4105 | Transcriptional regulation by RUNX1 |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-114516 | Disinhibition of SNARE formation |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-4419969 | Depolymerisation of the Nuclear Lamina |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5099900 | WNT5A-dependent internalization of FZD4 |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid cells |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | agpcrpathway | attenuation of gpcr signaling |
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | calcineurinpathway | effects of calcineurin in keratinocyte differentiation |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | cblpathway | cbl mediated ligand-induced downregulation of egf receptors pathway |
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| biocarta | cdmacpathway | cadmium induces dna synthesis and proliferation in macrophages |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | erbb4pathway | g-secretase mediated erbb4 signaling pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | ionpathway | ionomycin and phorbal ester signaling pathway |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | pkcpathway | activation of pkc through g-protein coupled receptors |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | sppapathway | aspirin blocks signaling pathway involved in platelet activation |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | trkapathway | trka receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD23 | Gossypol | 5 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD224 | Necrostatin-1 | 6 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD247 | Blebbistatin | 9 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD466 | Chaetocin | 5 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD147 | Prima-1 | 4 |
| iGMDRD329 | Merck60 | 11 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD213 | SMR000068650 | 6 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD268 | Cerulenin | 6 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD690 | PRIMA-1MET | 8 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD802 | 4-methylfasudil | 9 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD380 | Pifithrin-alpha | 9 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD1008 | SR-II-138A | 4 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD607 | Ubistatin B | 6 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD307 | Manumycin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCB
CLASSFICATION
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