PRKCB


Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase C betaMIM:176970Ensembl:ENSG00000166501HGNC:HGNC:9395PA3376116p12.2-p12.1

GO terms in PRKCB


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002250adaptive immune response
BPIEAGO:0006351transcription, DNA-templated
BPIMPGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006468protein phosphorylation
BPIEAGO:0006915apoptotic process
BPTASGO:0007077mitotic nuclear envelope disassembly
BPNASGO:0007165signal transduction
BPISSGO:0010829negative regulation of glucose transmembrane transport
BPIBAGO:0018105peptidyl-serine phosphorylation
BPTASGO:0030168platelet activation
BPISSGO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway
BPIDAGO:0035408histone H3-T6 phosphorylation
BPIBAGO:0035556intracellular signal transduction
BPISSGO:0042113B cell activation
BPTASGO:0042953lipoprotein transport
BPISSGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPTASGO:0045637regulation of myeloid cell differentiation
BPISSGO:0045766positive regulation of angiogenesis
BPISSGO:0046627negative regulation of insulin receptor signaling pathway
BPISSGO:0050853B cell receptor signaling pathway
BPISSGO:0050861positive regulation of B cell receptor signaling pathway
BPISSGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0070062extracellular exosome
MFIDAGO:0003682chromatin binding
MFEXPGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFTASGO:0004697protein kinase C activity
MFTASGO:0004698calcium-dependent protein kinase C activity
MFIPIGO:0005080protein kinase C binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008270zinc ion binding
MFIMPGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0035403histone kinase activity (H3-T6 specific)
MFIDAGO:0042393histone binding
MFIDAGO:0050681androgen receptor binding

Gene expression in normal tissue: PRKCB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKCB


DatabasePathway IDPathway Des.
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidendothelinpathwayEndothelins
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidil2_1pathwayIL2-mediated signaling events
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidras_pathwayRegulation of Ras family activation
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtcrjnkpathwayJNK signaling in the CD4+ TCR pathway
pidtcrraspathwayRas signaling in the CD4+ TCR pathway
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidtxa2pathwayThromboxane A2 receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidvegfr1_pathwayVEGFR1 specific signals
netpathPathway_BCRBCR
netpathPathway_CRHCRH
netpathPathway_EGFR1EGFR1
netpathPathway_GhrelinGhrelin
netpathPathway_IL11IL11
netpathPathway_IL3IL3
netpathPathway_KitReceptorKitReceptor
netpathPathway_WntWnt
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)
kegghsa04973Carbohydrate digestion and absorption - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
wikipathwaysWP1528Physiological and Pathological Hypertrophy of the Heart
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3944Serotonin and anxiety-related events
wikipathwaysWP3947Serotonin and anxiety
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4105Transcriptional regulation by RUNX1
wikipathwaysWP4223Ras Signaling
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-114516Disinhibition of SNARE formation
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2980766Nuclear Envelope Breakdown
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-416993Trafficking of GluR2-containing AMPA receptors
reactomeR-HSA-418597G alpha (z) signalling events
reactomeR-HSA-4419969Depolymerisation of the Nuclear Lamina
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5099900WNT5A-dependent internalization of FZD4
reactomeR-HSA-5218921VEGFR2 mediated cell proliferation
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939246RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
biocartaagpcrpathwayattenuation of gpcr signaling
biocartaarenrf2pathwayoxidative stress induced gene expression via nrf2
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartabcrpathwaybcr signaling pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacalcineurinpathwayeffects of calcineurin in keratinocyte differentiation
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartacblpathwaycbl mediated ligand-induced downregulation of egf receptors pathway
biocartaccr3pathwayccr3 signaling in eosinophils
biocartacdmacpathwaycadmium induces dna synthesis and proliferation in macrophages
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaegfpathwayegf signaling pathway
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaerbb4pathwayg-secretase mediated erbb4 signaling pathway
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartaghpathwaygrowth hormone signaling pathway
biocartagpcrpathwaysignaling pathway from g-protein families
biocartaionpathwayionomycin and phorbal ester signaling pathway
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamef2dpathwayrole of mef2d in t-cell apoptosis
biocartamyosinpathwaypkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
biocartanos1pathwaynitric oxide signaling pathway
biocartapar1pathwaythrombin signaling and protease-activated receptors
biocartapdgfpathwaypdgf signaling pathway
biocartapkcpathwayactivation of pkc through g-protein coupled receptors
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartasppapathwayaspirin blocks signaling pathway involved in platelet activation
biocartatcrpathwayt cell receptor signaling pathway
biocartatpopathwaytpo signaling pathway
biocartatrkapathwaytrka receptor signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD23Gossypol5
iGMDRD64Parbendazole1
iGMDRD369TGX-1153
iGMDRD888Compound 441
iGMDRD224Necrostatin-16
iGMDRD188Piperlongumine2
iGMDRD730Kahalalide F1
iGMDRD74Idarubicin2
iGMDRD399Selumetinib1
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD52Rotenone2
iGMDRD260FQI-22
iGMDRD247Blebbistatin9
iGMDRD513BML-2592
iGMDRD466Chaetocin5
iGMDRD152179324-69-71
iGMDRD670ML 2101
iGMDRD546BMS-7548072
iGMDRD427ABT7375
iGMDRD126Tipifarnib4
iGMDRD409Saracatinib1
iGMDRD151CHM-12
iGMDRD322FK 8662
iGMDRD147Prima-14
iGMDRD329Merck6011
iGMDRD286Nsc 6328394
iGMDRD871BRD63686
iGMDRD77Itraconazole5
iGMDRD213SMR0000686506
iGMDRD289Parthenolide2
iGMDRD221Tamoxifen2
iGMDRD103SN-382
iGMDRD121GMX17782
iGMDRD158NSC1415404
iGMDRD154NSC237662
iGMDRD219Bax channel blocker3
iGMDRD405PIK-752
iGMDRD560MK-22061
iGMDRD268Cerulenin6
iGMDRD451Serdemetan3
iGMDRD690PRIMA-1MET8
iGMDRD60Quinoclamine6
iGMDRD577BIX012946
iGMDRD887Compound 23 citrate1
iGMDRD318PAC-16
iGMDRD441TW 373
iGMDRD8024-methylfasudil9
iGMDRD255SB2250023
iGMDRD634SCHEMBL26080413
iGMDRD375GW-4058333
iGMDRD380Pifithrin-alpha9
iGMDRD201SKI II3
iGMDRD494Neopeltolide1
iGMDRD579PF7502
iGMDRD772BRD47706
iGMDRD1008SR-II-138A4
iGMDRD82Quiflapon3
iGMDRD872BRD71372
iGMDRD267Oligomycin A3
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD211(1S,3R)-RSL31
iGMDRD351GW843682X3
iGMDRD701NVP-AUY9221
iGMDRD512nutlin 35
iGMDRD607Ubistatin B6
iGMDRD148Pifithrin-mu3
iGMDRD307Manumycin A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCB

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