ID1
Summary: The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inhibitor of DNA binding 1, HLH protein | MIM:600349 | Ensembl:ENSG00000125968 | HGNC:HGNC:5360 | PA29608 | 20q11.21 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in ID1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001886 | endothelial cell morphogenesis |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0007507 | heart development |
| BP | IBA | GO:0007623 | circadian rhythm |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | TAS | GO:0010621 | negative regulation of transcription by transcription factor localization |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IBA | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0030509 | BMP signaling pathway |
| BP | IEA | GO:0031648 | protein destabilization |
| BP | IEA | GO:0032233 | positive regulation of actin filament bundle assembly |
| BP | IEA | GO:0032963 | collagen metabolic process |
| BP | IEA | GO:0036164 | cell-abiotic substrate adhesion |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043392 | negative regulation of DNA binding |
| BP | IEA | GO:0043408 | regulation of MAPK cascade |
| BP | IDA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0043534 | blood vessel endothelial cell migration |
| BP | IEA | GO:0045602 | negative regulation of endothelial cell differentiation |
| BP | IBA | GO:0045665 | negative regulation of neuron differentiation |
| BP | IEA | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | IEA | GO:0045765 | regulation of angiogenesis |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0046677 | response to antibiotic |
| BP | TAS | GO:0048514 | blood vessel morphogenesis |
| BP | IEA | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | IEA | GO:0050774 | negative regulation of dendrite morphogenesis |
| BP | IBA | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0060425 | lung morphogenesis |
| BP | IEA | GO:0060426 | lung vasculature development |
| BP | IEA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IEA | GO:0090074 | negative regulation of protein homodimerization activity |
| BP | IEA | GO:1901653 | cellular response to peptide |
| BP | IEA | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| BP | IEA | GO:1903351 | cellular response to dopamine |
| BP | IEA | GO:1990090 | cellular response to nerve growth factor stimulus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IC | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0005813 | centrosome |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | IBA | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0043621 | protein self-association |
| MF | IEA | GO:0047485 | protein N-terminus binding |
| MF | IEA | GO:0070628 | proteasome binding |
Gene expression in normal tissue: ID1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ID1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| pid | alk1pathway | ALK1 signaling events |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | il3_pathway | IL3-mediated signaling events |
| netpath | Pathway_ID | ID |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3596 | miR-517 relationship with ARCN1 and USP1 |
| wikipathways | WP3859 | TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
| wikipathways | WP3924 | Hfe effect on hepcidin production |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP53 | ID signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD67 | PENFLURIDOL | 4 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD409 | Saracatinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ID1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.