ID1


Summary: The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inhibitor of DNA binding 1, HLH proteinMIM:600349Ensembl:ENSG00000125968HGNC:HGNC:5360PA2960820q11.21

GO terms in ID1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0001525angiogenesis
BPIEAGO:0001886endothelial cell morphogenesis
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007420brain development
BPIEAGO:0007507heart development
BPIBAGO:0007623circadian rhythm
BPIEAGO:0007623circadian rhythm
BPTASGO:0010621negative regulation of transcription by transcription factor localization
BPIEAGO:0010628positive regulation of gene expression
BPIBAGO:0030182neuron differentiation
BPIEAGO:0030182neuron differentiation
BPIEAGO:0030509BMP signaling pathway
BPIEAGO:0031648protein destabilization
BPIEAGO:0032233positive regulation of actin filament bundle assembly
BPIEAGO:0032963collagen metabolic process
BPIEAGO:0036164cell-abiotic substrate adhesion
BPIEAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043392negative regulation of DNA binding
BPIEAGO:0043408regulation of MAPK cascade
BPIDAGO:0043433negative regulation of DNA-binding transcription factor activity
BPTASGO:0043534blood vessel endothelial cell migration
BPIEAGO:0045602negative regulation of endothelial cell differentiation
BPIBAGO:0045665negative regulation of neuron differentiation
BPIEAGO:0045668negative regulation of osteoblast differentiation
BPIEAGO:0045765regulation of angiogenesis
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0046677response to antibiotic
BPTASGO:0048514blood vessel morphogenesis
BPIEAGO:0050679positive regulation of epithelial cell proliferation
BPIEAGO:0050774negative regulation of dendrite morphogenesis
BPIBAGO:0051726regulation of cell cycle
BPIEAGO:0060425lung morphogenesis
BPIEAGO:0060426lung vasculature development
BPIEAGO:0071364cellular response to epidermal growth factor stimulus
BPIEAGO:0090074negative regulation of protein homodimerization activity
BPIEAGO:1901653cellular response to peptide
BPIEAGO:1903026negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
BPIEAGO:1903351cellular response to dopamine
BPIEAGO:1990090cellular response to nerve growth factor stimulus
CCIBAGO:0005634nucleus
CCICGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0005813centrosome
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001085RNA polymerase II transcription factor binding
MFIBAGO:0001191transcriptional repressor activity, RNA polymerase II transcription factor binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008022protein C-terminus binding
MFIBAGO:0008134transcription factor binding
MFIEAGO:0008134transcription factor binding
MFIEAGO:0042803protein homodimerization activity
MFIEAGO:0043621protein self-association
MFIEAGO:0047485protein N-terminus binding
MFIEAGO:0070628proteasome binding

Gene expression in normal tissue: ID1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ID1


DatabasePathway IDPathway Des.
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-8953897Cellular responses to external stimuli
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
pidalk1pathwayALK1 signaling events
pidhes_heypathwayNotch-mediated HES/HEY network
pidil3_pathwayIL3-mediated signaling events
netpathPathway_IDID
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3596miR-517 relationship with ARCN1 and USP1
wikipathwaysWP3859TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
wikipathwaysWP3924Hfe effect on hepcidin production
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP53ID signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD887Compound 23 citrate2
iGMDRD414MST-3122
iGMDRD67PENFLURIDOL4
iGMDRD577BIX012943
iGMDRD506Fedratinib2
iGMDRD524ISX-95
iGMDRD322FK 8663
iGMDRD23Gossypol3
iGMDRD121GMX17781
iGMDRD434BMS-5369242
iGMDRD6AM-5801
iGMDRD221Tamoxifen1
iGMDRD885Compound 1105
iGMDRD318PAC-11
iGMDRD441TW 371
iGMDRD152179324-69-71
iGMDRD237ABT-7512
iGMDRD409Saracatinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ID1

​​​​