ID1

Summary: The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinhibitor of DNA binding 1, HLH protein
OMIM IDMIM:600349
Ensembl IDEnsembl:ENSG00000125968
HGNC IDHGNC:HGNC:5360
PHARMGKB IDPA29608
Map Location20q11.21

GO terms in ID1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0000122 negative regulation of transcription by RNA polymerase II
BP TAS GO:0001525 angiogenesis
BP IEA GO:0001886 endothelial cell morphogenesis
BP IEA GO:0006351 transcription, DNA-templated
BP TAS GO:0007179 transforming growth factor beta receptor signaling pathway
BP IEA GO:0007420 brain development
Showing 1 to 6 of 61 rows rows per page

Gene expression in normal tissue: ID1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 28LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 13

Gene-drug pathway distribution

Pathways in ID1


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-2262752 Cellular responses to stress
reactome R-HSA-2559583 Cellular Senescence
reactome R-HSA-2559585 Oncogene Induced Senescence
reactome R-HSA-8953897 Cellular responses to external stimuli
kegg hsa04015 Rap1 signaling pathway - Homo sapiens (human)
kegg hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
Showing 1 to 6 of 19 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD887 Compound 23 citrate 2
iGMDRD414 MST-312 2
iGMDRD67 PENFLURIDOL 4
iGMDRD577 BIX01294 3
Showing 1 to 4 of 18 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ID1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.