CARD9


Summary: The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
caspase recruitment domain family member 9MIM:607212Ensembl:ENSG00000187796HGNC:HGNC:16391PA260779q34.3

Gene Categories:

DRUG RESISTANCE

GO terms in CARD9


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIEAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0009620response to fungus
BPIEAGO:0032494response to peptidoglycan
BPIEAGO:0032495response to muramyl dipeptide
BPIEAGO:0032755positive regulation of interleukin-6 production
BPIEAGO:0032760positive regulation of tumor necrosis factor production
BPIDAGO:0032874positive regulation of stress-activated MAPK cascade
BPIEAGO:0042534regulation of tumor necrosis factor biosynthetic process
BPIEAGO:0042981regulation of apoptotic process
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043330response to exogenous dsRNA
BPIEAGO:0045076regulation of interleukin-2 biosynthetic process
BPIEAGO:0045087innate immune response
BPIEAGO:0045408regulation of interleukin-6 biosynthetic process
BPIDAGO:0046330positive regulation of JNK cascade
BPIEAGO:0050830defense response to Gram-positive bacterium
BPIEAGO:0051607defense response to virus
MFIPIGO:0005515protein binding
MFIPIGO:0042803protein homodimerization activity
MFIPIGO:0050700CARD domain binding

Gene expression in normal tissue: CARD9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CARD9


DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD5Tyrphostin AG 14783
iGMDRD599Salermide6
iGMDRD330BRD41321
iGMDRD267Oligomycin A3
iGMDRD221Tamoxifen3
iGMDRD2PK-111953
iGMDRD577BIX012943
iGMDRD329Merck601
iGMDRD85Ursolic acid3
iGMDRD188Piperlongumine3
iGMDRD286Nsc 6328393
iGMDRD341Triacsin c1
iGMDRD375GW-4058333

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CARD9

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