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CARD9

Summary: The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
caspase recruitment domain family member 9	MIM:607212	Ensembl:ENSG00000187796	HGNC:HGNC:16391	PA26077	9q34.3

Gene Categories:

DRUG RESISTANCE

GO terms in CARD9

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
CC	TAS	GO:0005886	plasma membrane
BP	TAS	GO:0002223	stimulatory C-type lectin receptor signaling pathway
BP	IEA	GO:0007249	I-kappaB kinase/NF-kappaB signaling
BP	IEA	GO:0009620	response to fungus
BP	IEA	GO:0032494	response to peptidoglycan
BP	IEA	GO:0032495	response to muramyl dipeptide
BP	IEA	GO:0032755	positive regulation of interleukin-6 production
BP	IEA	GO:0032760	positive regulation of tumor necrosis factor production
BP	IDA	GO:0032874	positive regulation of stress-activated MAPK cascade
BP	IEA	GO:0042534	regulation of tumor necrosis factor biosynthetic process
BP	IEA	GO:0042981	regulation of apoptotic process
BP	IEP	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
BP	IEA	GO:0043330	response to exogenous dsRNA
BP	IEA	GO:0045076	regulation of interleukin-2 biosynthetic process
BP	IEA	GO:0045087	innate immune response
BP	IEA	GO:0045408	regulation of interleukin-6 biosynthetic process
BP	IDA	GO:0046330	positive regulation of JNK cascade
BP	IEA	GO:0050830	defense response to Gram-positive bacterium
BP	IEA	GO:0051607	defense response to virus
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0042803	protein homodimerization activity
MF	IPI	GO:0050700	CARD domain binding

Gene expression in normal tissue: CARD9

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CARD9

Database	Pathway ID	Pathway Des.
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168638	NOD1/2 Signaling Pathway
reactome	R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactome	R-HSA-5607764	CLEC7A (Dectin-1) signaling
reactome	R-HSA-5621481	C-type lectin receptors (CLRs)
wikipathways	WP1433	Nucleotide-binding Oligomerization Domain (NOD) pathway
kegg	hsa04621	NOD-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04625	C-type lectin receptor signaling pathway - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD599	Salermide	6
iGMDRD330	BRD4132	1
iGMDRD267	Oligomycin A	3
iGMDRD221	Tamoxifen	3
iGMDRD2	PK-11195	3
iGMDRD577	BIX01294	3
iGMDRD329	Merck60	1
iGMDRD85	Ursolic acid	3
iGMDRD188	Piperlongumine	3
iGMDRD286	Nsc 632839	3
iGMDRD341	Triacsin c	1
iGMDRD375	GW-405833	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CARD9

SITE

DATATYPES

CLASSFICATION

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