PRKAA2
Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase AMP-activated catalytic subunit alpha 2 | MIM:600497 | Ensembl:ENSG00000162409 | HGNC:HGNC:9377 | PA33745 | 1p32.2 |
GO terms in PRKAA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0010494 | cytoplasmic stress granule |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IBA | GO:0031588 | nucleotide-activated protein kinase complex |
| CC | ISS | GO:0043025 | neuronal cell body |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006633 | fatty acid biosynthetic process |
| BP | IEA | GO:0006695 | cholesterol biosynthetic process |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0008610 | lipid biosynthetic process |
| BP | ISS | GO:0010508 | positive regulation of autophagy |
| BP | ISS | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0014850 | response to muscle activity |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | TAS | GO:0016239 | positive regulation of macroautophagy |
| BP | ISS | GO:0016241 | regulation of macroautophagy |
| BP | ISS | GO:0031669 | cellular response to nutrient levels |
| BP | IBA | GO:0032007 | negative regulation of TOR signaling |
| BP | ISS | GO:0032007 | negative regulation of TOR signaling |
| BP | ISS | GO:0034599 | cellular response to oxidative stress |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0035690 | cellular response to drug |
| BP | IBA | GO:0042149 | cellular response to glucose starvation |
| BP | ISS | GO:0042149 | cellular response to glucose starvation |
| BP | TAS | GO:0042304 | regulation of fatty acid biosynthetic process |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | ISS | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0045821 | positive regulation of glycolytic process |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | ISS | GO:0055089 | fatty acid homeostasis |
| BP | ISS | GO:0070507 | regulation of microtubule cytoskeleton organization |
| BP | ISS | GO:0071277 | cellular response to calcium ion |
| BP | ISS | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071380 | cellular response to prostaglandin E stimulus |
| BP | ISS | GO:0097009 | energy homeostasis |
| BP | ISS | GO:1903829 | positive regulation of cellular protein localization |
| BP | ISS | GO:1904428 | negative regulation of tubulin deacetylation |
| BP | ISS | GO:2000758 | positive regulation of peptidyl-lysine acetylation |
| MF | ISS | GO:0003682 | chromatin binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004679 | AMP-activated protein kinase activity |
| MF | ISS | GO:0004679 | AMP-activated protein kinase activity |
| MF | IDA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0035174 | histone serine kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0047322 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity |
| MF | IEA | GO:0050405 | [acetyl-CoA carboxylase] kinase activity |
Gene expression in normal tissue: PRKAA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKAA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_Leptin | Leptin |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3961 | fig-met-1-last-solution |
| wikipathways | WP3965 | Lipid Metabolism Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4141 | PI3K-AKT-mTOR - VitD3 Signalling |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity |
| reactome | R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-200425 | Import of palmitoyl-CoA into the mitochondrial matrix |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | leptinpathway | reversal of insulin resistance by leptin |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD188 | Piperlongumine | 7 |
| iGMDRD804 | ACLY SiRNA | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD690 | PRIMA-1MET | 6 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD147 | Prima-1 | 4 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD227 | Fatostatin A | 3 |
| iGMDRD221 | Tamoxifen | 4 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD79 | Gemcitabine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKAA2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.