PRKAA2


Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase AMP-activated catalytic subunit alpha 2MIM:600497Ensembl:ENSG00000162409HGNC:HGNC:9377PA337451p32.2

GO terms in PRKAA2


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCTASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCISSGO:0010494cytoplasmic stress granule
CCIDAGO:0016607nuclear speck
CCISSGO:0030424axon
CCISSGO:0030425dendrite
CCIBAGO:0031588nucleotide-activated protein kinase complex
CCISSGO:0043025neuronal cell body
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0006468protein phosphorylation
BPTASGO:0006468protein phosphorylation
BPIEAGO:0006633fatty acid biosynthetic process
BPIEAGO:0006695cholesterol biosynthetic process
BPTASGO:0007050cell cycle arrest
BPTASGO:0007165signal transduction
BPISSGO:0008610lipid biosynthetic process
BPISSGO:0010508positive regulation of autophagy
BPISSGO:0010629negative regulation of gene expression
BPIEAGO:0014850response to muscle activity
BPIEAGO:0016055Wnt signaling pathway
BPTASGO:0016236macroautophagy
BPTASGO:0016239positive regulation of macroautophagy
BPISSGO:0016241regulation of macroautophagy
BPISSGO:0031669cellular response to nutrient levels
BPIBAGO:0032007negative regulation of TOR signaling
BPISSGO:0032007negative regulation of TOR signaling
BPISSGO:0034599cellular response to oxidative stress
BPIBAGO:0035556intracellular signal transduction
BPIEAGO:0035690cellular response to drug
BPIBAGO:0042149cellular response to glucose starvation
BPISSGO:0042149cellular response to glucose starvation
BPTASGO:0042304regulation of fatty acid biosynthetic process
BPISSGO:0042593glucose homeostasis
BPISSGO:0042752regulation of circadian rhythm
BPISSGO:0043066negative regulation of apoptotic process
BPISSGO:0045821positive regulation of glycolytic process
BPIEAGO:0048511rhythmic process
BPISSGO:0055089fatty acid homeostasis
BPISSGO:0070507regulation of microtubule cytoskeleton organization
BPISSGO:0071277cellular response to calcium ion
BPISSGO:0071333cellular response to glucose stimulus
BPIEAGO:0071380cellular response to prostaglandin E stimulus
BPISSGO:0097009energy homeostasis
BPISSGO:1903829positive regulation of cellular protein localization
BPISSGO:1904428negative regulation of tubulin deacetylation
BPISSGO:2000758positive regulation of peptidyl-lysine acetylation
MFISSGO:0003682chromatin binding
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004679AMP-activated protein kinase activity
MFISSGO:0004679AMP-activated protein kinase activity
MFIDAGO:0004712protein serine/threonine/tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFISSGO:0035174histone serine kinase activity
MFIEAGO:0046872metal ion binding
MFIEAGO:0047322[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
MFIEAGO:0050405[acetyl-CoA carboxylase] kinase activity

Gene expression in normal tissue: PRKAA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKAA2


DatabasePathway IDPathway Des.
pharmgkbPA165948566Metformin Pathway, Pharmacodynamic
pharmgkbPA165984799Diuretics Pathway, Pharmacodynamics
netpathPathway_EGFR1EGFR1
netpathPathway_GhrelinGhrelin
netpathPathway_LeptinLeptin
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04710Circadian rhythm - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP1471Target Of Rapamycin (TOR) Signaling
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3961fig-met-1-last-solution
wikipathwaysWP3965Lipid Metabolism Pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP4141PI3K-AKT-mTOR - VitD3 Signalling
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP481Insulin Signaling
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1445148Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1632852Macroautophagy
reactomeR-HSA-163680AMPK inhibits chREBP transcriptional activation activity
reactomeR-HSA-163680AMPK inhibits chREBP transcriptional activation activity
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-165159mTOR signalling
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-200425Import of palmitoyl-CoA into the mitochondrial matrix
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylation
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPK
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8978868Fatty acid metabolism
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartaleptinpathwayreversal of insulin resistance by leptin

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD188Piperlongumine7
iGMDRD804ACLY SiRNA1
iGMDRD64Parbendazole3
iGMDRD690PRIMA-1MET6
iGMDRD524ISX-93
iGMDRD268Cerulenin2
iGMDRD138PX 123
iGMDRD870BRD636103
iGMDRD52Rotenone2
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD446LY 21832403
iGMDRD466Chaetocin2
iGMDRD772BRD47702
iGMDRD889Compound 7d-cis6
iGMDRD144NSC953975
iGMDRD872BRD71373
iGMDRD871BRD63685
iGMDRD286Nsc 6328392
iGMDRD329Merck605
iGMDRD147Prima-14
iGMDRD300Tozasertib6
iGMDRD322FK 8662
iGMDRD158NSC1415403
iGMDRD121GMX17782
iGMDRD227Fatostatin A3
iGMDRD221Tamoxifen4
iGMDRD289Parthenolide3
iGMDRD57Chloropentafluorobenzene2
iGMDRD211(1S,3R)-RSL33
iGMDRD307Manumycin A3
iGMDRD512nutlin 31
iGMDRD79Gemcitabine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAA2

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