PRKAA2


Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in PRKAA2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC TAS GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IBA GO:0005737 cytoplasm
CC IDA GO:0005794 Golgi apparatus
CC TAS GO:0005829 cytosol
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Gene expression in normal tissue: PRKAA2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 54LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 39UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 7BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1

Gene-drug pathway distribution

undefined24Chromatin histone acetylation1Ferroptosis1Purine metabolism1Drug metabolism - cytochrome P4501DNA replication1Biosynthesis of secondary metabolites1Mitosis1Metabolism1

Pathways in PRKAA2


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Database
Pathway ID
Pathway Des.
pharmgkb PA165948566 Metformin Pathway, Pharmacodynamic
pharmgkb PA165984799 Diuretics Pathway, Pharmacodynamics
netpath Pathway_EGFR1 EGFR1
netpath Pathway_Ghrelin Ghrelin
netpath Pathway_Leptin Leptin
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD188 Piperlongumine 7
iGMDRD804 ACLY SiRNA 1
iGMDRD64 Parbendazole 3
iGMDRD690 PRIMA-1MET 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAA2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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