PRKAA2
Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:600497 Ensembl IDEnsembl:ENSG00000162409 HGNC IDHGNC:HGNC:9377 PHARMGKB IDPA33745 Map Location1p32.2 |
GO terms in PRKAA2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005634 | nucleus |
CC | TAS | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IBA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005794 | Golgi apparatus |
CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: PRKAA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKAA2
Database | Pathway ID | Pathway Des. |
---|---|---|
pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
netpath | Pathway_EGFR1 | EGFR1 |
netpath | Pathway_Ghrelin | Ghrelin |
netpath | Pathway_Leptin | Leptin |
kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PRKAA2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |