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PRKAA2

Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameprotein kinase AMP-activated catalytic subunit alpha 2 OMIM IDMIM:600497 Ensembl IDEnsembl:ENSG00000162409 HGNC IDHGNC:HGNC:9377 PHARMGKB IDPA33745 Map Location1p32.2

Gene Categories:

TUMOR SUPPRESSOR KINASE SERINE THREONINE KINASE DRUGGABLE GENOME HISTONE MODIFICATION DRUG RESISTANCE

GO terms in PRKAA2

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0005634	nucleus
CC	TAS	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005794	Golgi apparatus
CC	TAS	GO:0005829	cytosol

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Gene expression in normal tissue: PRKAA2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKAA2

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Database	Pathway ID	Pathway Des.
pharmgkb	PA165948566	Metformin Pathway, Pharmacodynamic
pharmgkb	PA165984799	Diuretics Pathway, Pharmacodynamics
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_Ghrelin	Ghrelin
netpath	Pathway_Leptin	Leptin
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD188	Piperlongumine	7
iGMDRD804	ACLY SiRNA	1
iGMDRD64	Parbendazole	3
iGMDRD690	PRIMA-1MET	6

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAA2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.