BIRC2
Summary: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| baculoviral IAP repeat containing 2 | MIM:601712 | Ensembl:ENSG00000110330 | HGNC:HGNC:590 | PA25359 | 11q22.2 |
GO terms in BIRC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0003713 | transcription coactivator activity |
| MF | EXP | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | EXP | GO:0016740 | transferase activity |
| MF | IBA | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| MF | IDA | GO:0043130 | ubiquitin binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | IPI | GO:0051087 | chaperone binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| MF | IPI | GO:0098770 | FBXO family protein binding |
| CC | IEA | GO:0001741 | XY body |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0009898 | cytoplasmic side of plasma membrane |
| CC | ISS | GO:0035631 | CD40 receptor complex |
| CC | IEA | GO:0045121 | membrane raft |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001890 | placenta development |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0034121 | regulation of toll-like receptor signaling pathway |
| BP | TAS | GO:0038061 | NIK/NF-kappaB signaling |
| BP | TAS | GO:0039535 | regulation of RIG-I signaling pathway |
| BP | TAS | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0045088 | regulation of innate immune response |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | TAS | GO:0045595 | regulation of cell differentiation |
| BP | TAS | GO:0050727 | regulation of inflammatory response |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | IDA | GO:0051726 | regulation of cell cycle |
| BP | IMP | GO:0060544 | regulation of necroptotic process |
| BP | TAS | GO:0060544 | regulation of necroptotic process |
| BP | IBA | GO:0060546 | negative regulation of necroptotic process |
| BP | IEA | GO:0070266 | necroptotic process |
| BP | TAS | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| BP | IBA | GO:0090307 | mitotic spindle assembly |
| BP | IEA | GO:1901222 | regulation of NIK/NF-kappaB signaling |
| BP | IEA | GO:1902443 | negative regulation of ripoptosome assembly involved in necroptotic process |
| BP | IDA | GO:1902523 | positive regulation of protein K63-linked ubiquitination |
| BP | IDA | GO:1902524 | positive regulation of protein K48-linked ubiquitination |
| BP | IDA | GO:1902527 | positive regulation of protein monoubiquitination |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
| BP | IBA | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:2000116 | regulation of cysteine-type endopeptidase activity |
| BP | IEA | GO:2000377 | regulation of reactive oxygen species metabolic process |
Gene expression in normal tissue: BIRC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BIRC2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | tnfpathway | TNF receptor signaling pathway |
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TWEAK | TWEAK |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-937041 | IKK complex recruitment mediated by RIP1 |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD499 | PDMP | 6 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD307 | Manumycin A | 6 |
| iGMDRD82 | Quiflapon | 6 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD221 | Tamoxifen | 5 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD484 | Pluripotin | 5 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD255 | SB225002 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BIRC2
CLASSFICATION
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