BIRC2


Summary: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
baculoviral IAP repeat containing 2MIM:601712Ensembl:ENSG00000110330HGNC:HGNC:590PA2535911q22.2

GO terms in BIRC2


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0003713transcription coactivator activity
MFEXPGO:0004842ubiquitin-protein transferase activity
MFIDAGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIDAGO:0008270zinc ion binding
MFEXPGO:0016740transferase activity
MFIBAGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process
MFIDAGO:0043130ubiquitin binding
MFIPIGO:0047485protein N-terminus binding
MFIPIGO:0051087chaperone binding
MFIBAGO:0061630ubiquitin protein ligase activity
MFIPIGO:0098770FBXO family protein binding
CCIEAGO:0001741XY body
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCISSGO:0009898cytoplasmic side of plasma membrane
CCISSGO:0035631CD40 receptor complex
CCIEAGO:0045121membrane raft
BPIDAGO:0000209protein polyubiquitination
BPIEAGO:0001666response to hypoxia
BPIEAGO:0001890placenta development
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006915apoptotic process
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPTASGO:0016579protein deubiquitination
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPTASGO:0034121regulation of toll-like receptor signaling pathway
BPTASGO:0038061NIK/NF-kappaB signaling
BPTASGO:0039535regulation of RIG-I signaling pathway
BPTASGO:0042127regulation of cell proliferation
BPIMPGO:0042981regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPTASGO:0045088regulation of innate immune response
BPIEAGO:0045471response to ethanol
BPTASGO:0045595regulation of cell differentiation
BPTASGO:0050727regulation of inflammatory response
BPIEAGO:0051291protein heterooligomerization
BPIEAGO:0051591response to cAMP
BPIDAGO:0051726regulation of cell cycle
BPIMPGO:0060544regulation of necroptotic process
BPTASGO:0060544regulation of necroptotic process
BPIBAGO:0060546negative regulation of necroptotic process
BPIEAGO:0070266necroptotic process
BPTASGO:0070424regulation of nucleotide-binding oligomerization domain containing signaling pathway
BPIBAGO:0090307mitotic spindle assembly
BPIEAGO:1901222regulation of NIK/NF-kappaB signaling
BPIEAGO:1902443negative regulation of ripoptosome assembly involved in necroptotic process
BPIDAGO:1902523positive regulation of protein K63-linked ubiquitination
BPIDAGO:1902524positive regulation of protein K48-linked ubiquitination
BPIDAGO:1902527positive regulation of protein monoubiquitination
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
BPIBAGO:1990001inhibition of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:2000116regulation of cysteine-type endopeptidase activity
BPIEAGO:2000377regulation of reactive oxygen species metabolic process

Gene expression in normal tissue: BIRC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BIRC2


DatabasePathway IDPathway Des.
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP2880Glucocorticoid Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
pidcd40_pathwayCD40/CD40L signaling
pidfaspathwayFAS (CD95) signaling pathway
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
pidtnfpathwayTNF receptor signaling pathway
pharmgkbPA165374494Busulfan Pathway, Pharmacodynamics
netpathPathway_TNFalphaTNFalpha
netpathPathway_TWEAKTWEAK
biocartacaspasepathwaycaspase cascade in apoptosis
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamitochondriapathwayrole of mitochondria in apoptotic signaling
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5675482Regulation of necroptotic cell death
reactomeR-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75153Apoptotic execution phase
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-937041IKK complex recruitment mediated by RIP1
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD132(-)-gallocatechin-3-O-gallate5
iGMDRD57Chloropentafluorobenzene2
iGMDRD499PDMP6
iGMDRD237ABT-7512
iGMDRD341Triacsin c2
iGMDRD532Olaparib3
iGMDRD307Manumycin A6
iGMDRD82Quiflapon6
iGMDRD886Compound 1541A2
iGMDRD329Merck605
iGMDRD366PI-1032
iGMDRD871BRD63686
iGMDRD872BRD71372
iGMDRD415LE-1353
iGMDRD221Tamoxifen5
iGMDRD705Nakiterpiosin5
iGMDRD434BMS-5369241
iGMDRD202Curcumin3
iGMDRD271Brefeldin A3
iGMDRD634SCHEMBL26080412
iGMDRD280CYTOCHALASIN B6
iGMDRD679Bistramide A3
iGMDRD61Kinetin riboside6
iGMDRD446LY 21832402
iGMDRD484Pluripotin5
iGMDRD772BRD47706
iGMDRD524ISX-93
iGMDRD451Serdemetan1
iGMDRD60Quinoclamine4
iGMDRD506Fedratinib6
iGMDRD577BIX012942
iGMDRD780PP-303
iGMDRD188Piperlongumine2
iGMDRD100Zebularine1
iGMDRD887Compound 23 citrate3
iGMDRD318PAC-12
iGMDRD255SB2250021

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BIRC2

​​​​