BIRC2

Summary: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namebaculoviral IAP repeat containing 2
OMIM IDMIM:601712
Ensembl IDEnsembl:ENSG00000110330
HGNC IDHGNC:HGNC:590
PHARMGKB IDPA25359
Map Location11q22.2

GO terms in BIRC2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IMP GO:0003713 transcription coactivator activity
MF EXP GO:0004842 ubiquitin-protein transferase activity
MF IDA GO:0004842 ubiquitin-protein transferase activity
MF TAS GO:0004842 ubiquitin-protein transferase activity
MF IPI GO:0005515 protein binding
MF IDA GO:0008270 zinc ion binding
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Gene expression in normal tissue: BIRC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30Other, kinases1Apoptosis regulation1p53 pathway1Drug metabolism - cytochrome P4501Genome integrity1PI3K/MTOR signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1

Pathways in BIRC2


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Database
Pathway ID
Pathway Des.
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP2036 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathways WP231 TNF alpha Signaling Pathway
wikipathways WP254 Apoptosis
wikipathways WP2880 Glucocorticoid Receptor Pathway
wikipathways WP2882 Nuclear Receptors Meta-Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD132 (-)-gallocatechin-3-O-gallate 5
iGMDRD57 Chloropentafluorobenzene 2
iGMDRD499 PDMP 6
iGMDRD237 ABT-751 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BIRC2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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