ARHGEF7

Summary: This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRho guanine nucleotide exchange factor 7
OMIM IDMIM:605477
Ensembl IDEnsembl:ENSG00000102606
HGNC IDHGNC:HGNC:15607
PHARMGKB IDPA24977
Map Location13q34

GO terms in ARHGEF7


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Term Type
Evidence Type
GO Term ID
GO Des.
MF EXP GO:0005085 guanyl-nucleotide exchange factor activity
MF IDA GO:0005085 guanyl-nucleotide exchange factor activity
MF TAS GO:0005085 guanyl-nucleotide exchange factor activity
MF TAS GO:0005089 Rho guanyl-nucleotide exchange factor activity
MF IPI GO:0005515 protein binding
MF IPI GO:0019901 protein kinase binding
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Gene expression in normal tissue: ARHGEF7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined44Apoptosis regulation3PI3K/MTOR signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Drug metabolism - cytochrome P4501Chromatin histone acetylation1Purine metabolism1Cell cycle1Mitosis1IGFR signaling1

Pathways in ARHGEF7


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Database
Pathway ID
Pathway Des.
pid aurora_a_pathway Aurora A signaling
pid cdc42_pathway CDC42 signaling events
pid cdc42_reg_pathway Regulation of CDC42 activity
pid erbb1_internalization_pathway Internalization of ErbB1
pid fak_pathway Signaling events mediated by focal adhesion kinase
pid ilk_pathway Integrin-linked kinase signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD398 Sepantronium 8
iGMDRD577 BIX01294 4
iGMDRD506 Fedratinib 3
iGMDRD888 Compound 44 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGEF7

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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