RBPJ
Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| recombination signal binding protein for immunoglobulin kappa J region | MIM:147183 | Ensembl:ENSG00000168214 | HGNC:HGNC:5724 | PA34292 | 4p15.2 |
GO terms in RBPJ
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001756 | somitogenesis |
| BP | ISS | GO:0001837 | epithelial to mesenchymal transition |
| BP | IEA | GO:0001974 | blood vessel remodeling |
| BP | IEA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | IEA | GO:0003139 | secondary heart field specification |
| BP | ISS | GO:0003151 | outflow tract morphogenesis |
| BP | ISS | GO:0003160 | endocardium morphogenesis |
| BP | IEA | GO:0003176 | aortic valve development |
| BP | IEA | GO:0003177 | pulmonary valve development |
| BP | ISS | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| BP | ISS | GO:0003214 | cardiac left ventricle morphogenesis |
| BP | ISS | GO:0003222 | ventricular trabecula myocardium morphogenesis |
| BP | ISS | GO:0003256 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| BP | NAS | GO:0006310 | DNA recombination |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0006959 | humoral immune response |
| BP | IBA | GO:0007219 | Notch signaling pathway |
| BP | IMP | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | IDA | GO:0007221 | positive regulation of transcription of Notch receptor target |
| BP | TAS | GO:0007221 | positive regulation of transcription of Notch receptor target |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009912 | auditory receptor cell fate commitment |
| BP | IEA | GO:0009957 | epidermal cell fate specification |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0021983 | pituitary gland development |
| BP | IEA | GO:0030183 | B cell differentiation |
| BP | IEA | GO:0030216 | keratinocyte differentiation |
| BP | ISS | GO:0030279 | negative regulation of ossification |
| BP | ISS | GO:0030513 | positive regulation of BMP signaling pathway |
| BP | IEA | GO:0035019 | somatic stem cell population maintenance |
| BP | ISS | GO:0035912 | dorsal aorta morphogenesis |
| BP | ISS | GO:0036302 | atrioventricular canal development |
| BP | IEA | GO:0042742 | defense response to bacterium |
| BP | IEA | GO:0043011 | myeloid dendritic cell differentiation |
| BP | IEA | GO:0045596 | negative regulation of cell differentiation |
| BP | TAS | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048505 | regulation of timing of cell differentiation |
| BP | IEA | GO:0048733 | sebaceous gland development |
| BP | IEA | GO:0048820 | hair follicle maturation |
| BP | ISS | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | IEA | GO:0060412 | ventricular septum morphogenesis |
| BP | IEA | GO:0060486 | Clara cell differentiation |
| BP | ISS | GO:0060716 | labyrinthine layer blood vessel development |
| BP | IEA | GO:0060844 | arterial endothelial cell fate commitment |
| BP | IC | GO:0061314 | Notch signaling involved in heart development |
| BP | IDA | GO:0061419 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | ISS | GO:0072554 | blood vessel lumenization |
| BP | IEA | GO:0072602 | interleukin-4 secretion |
| BP | ISS | GO:0097101 | blood vessel endothelial cell fate specification |
| BP | ISS | GO:1901186 | positive regulation of ERBB signaling pathway |
| BP | ISS | GO:1901189 | positive regulation of ephrin receptor signaling pathway |
| BP | IEA | GO:1901297 | positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment |
| BP | ISS | GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis |
| CC | IBA | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex |
| CC | IDA | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
| MF | NAS | GO:0000150 | recombinase activity |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | IPI | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IEA | GO:0047485 | protein N-terminus binding |
| MF | IBA | GO:0070491 | repressing transcription factor binding |
| MF | IPI | GO:0070491 | repressing transcription factor binding |
Gene expression in normal tissue: RBPJ
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBPJ
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-186712 | Regulation of beta-cell development |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription |
| reactome | R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-350054 | Notch-HLH transcription pathway |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8941856 | RUNX3 regulates NOTCH signaling |
| reactome | R-HSA-8941856 | RUNX3 regulates NOTCH signaling |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
| biocarta | hespathway | segmentation clock |
| biocarta | notchpathway | proteolysis and signaling pathway of notch |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | notch_pathway | Notch signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| netpath | Pathway_Notch | Notch |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP4147 | PTF1A related regulatory pathway |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD77 | Itraconazole | 4 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD560 | MK-2206 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBPJ
CLASSFICATION
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