RBPJ


Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
recombination signal binding protein for immunoglobulin kappa J regionMIM:147183Ensembl:ENSG00000168214HGNC:HGNC:5724PA342924p15.2

GO terms in RBPJ


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001525angiogenesis
BPIEAGO:0001756somitogenesis
BPISSGO:0001837epithelial to mesenchymal transition
BPIEAGO:0001974blood vessel remodeling
BPIEAGO:0002437inflammatory response to antigenic stimulus
BPIEAGO:0003139secondary heart field specification
BPISSGO:0003151outflow tract morphogenesis
BPISSGO:0003160endocardium morphogenesis
BPIEAGO:0003176aortic valve development
BPIEAGO:0003177pulmonary valve development
BPISSGO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation
BPISSGO:0003214cardiac left ventricle morphogenesis
BPISSGO:0003222ventricular trabecula myocardium morphogenesis
BPISSGO:0003256regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
BPNASGO:0006310DNA recombination
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIEAGO:0006959humoral immune response
BPIBAGO:0007219Notch signaling pathway
BPIMPGO:0007219Notch signaling pathway
BPTASGO:0007219Notch signaling pathway
BPIDAGO:0007221positive regulation of transcription of Notch receptor target
BPTASGO:0007221positive regulation of transcription of Notch receptor target
BPIEAGO:0008285negative regulation of cell proliferation
BPIEAGO:0009912auditory receptor cell fate commitment
BPIEAGO:0009957epidermal cell fate specification
BPISSGO:0010628positive regulation of gene expression
BPIEAGO:0021983pituitary gland development
BPIEAGO:0030183B cell differentiation
BPIEAGO:0030216keratinocyte differentiation
BPISSGO:0030279negative regulation of ossification
BPISSGO:0030513positive regulation of BMP signaling pathway
BPIEAGO:0035019somatic stem cell population maintenance
BPISSGO:0035912dorsal aorta morphogenesis
BPISSGO:0036302atrioventricular canal development
BPIEAGO:0042742defense response to bacterium
BPIEAGO:0043011myeloid dendritic cell differentiation
BPIEAGO:0045596negative regulation of cell differentiation
BPTASGO:0045747positive regulation of Notch signaling pathway
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048505regulation of timing of cell differentiation
BPIEAGO:0048733sebaceous gland development
BPIEAGO:0048820hair follicle maturation
BPISSGO:0060045positive regulation of cardiac muscle cell proliferation
BPIEAGO:0060412ventricular septum morphogenesis
BPIEAGO:0060486Clara cell differentiation
BPISSGO:0060716labyrinthine layer blood vessel development
BPIEAGO:0060844arterial endothelial cell fate commitment
BPICGO:0061314Notch signaling involved in heart development
BPIDAGO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPISSGO:0072554blood vessel lumenization
BPIEAGO:0072602interleukin-4 secretion
BPISSGO:0097101blood vessel endothelial cell fate specification
BPISSGO:1901186positive regulation of ERBB signaling pathway
BPISSGO:1901189positive regulation of ephrin receptor signaling pathway
BPIEAGO:1901297positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
BPISSGO:2000138positive regulation of cell proliferation involved in heart morphogenesis
CCIBAGO:0002193MAML1-RBP-Jkappa- ICN1 complex
CCIDAGO:0002193MAML1-RBP-Jkappa- ICN1 complex
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005667transcription factor complex
CCIEAGO:0005667transcription factor complex
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIDAGO:0017053transcriptional repressor complex
MFNASGO:0000150recombinase activity
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001103RNA polymerase II repressing transcription factor binding
MFIPIGO:0001103RNA polymerase II repressing transcription factor binding
MFTASGO:0003677DNA binding
MFIEAGO:0003682chromatin binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008134transcription factor binding
MFIPIGO:0008134transcription factor binding
MFIBAGO:0043565sequence-specific DNA binding
MFIDAGO:0043565sequence-specific DNA binding
MFIEAGO:0047485protein N-terminus binding
MFIBAGO:0070491repressing transcription factor binding
MFIPIGO:0070491repressing transcription factor binding

Gene expression in normal tissue: RBPJ

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RBPJ


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-210744Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2197563NOTCH2 intracellular domain regulates transcription
reactomeR-HSA-2197563NOTCH2 intracellular domain regulates transcription
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-350054Notch-HLH transcription pathway
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8941856RUNX3 regulates NOTCH signaling
reactomeR-HSA-8941856RUNX3 regulates NOTCH signaling
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013695NOTCH4 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013695NOTCH4 Intracellular Domain Regulates Transcription
biocartahespathwaysegmentation clock
biocartanotchpathwayproteolysis and signaling pathway of notch
pidhes_heypathwayNotch-mediated HES/HEY network
pidnotch_pathwayNotch signaling pathway
pidps1pathwayPresenilin action in Notch and Wnt signaling
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
netpathPathway_NotchNotch
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP3845Canonical and Non-canonical Notch signaling
wikipathwaysWP4147PTF1A related regulatory pathway
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP61Notch Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD562Navitoclax6
iGMDRD577BIX012943
iGMDRD871BRD63683
iGMDRD188Piperlongumine5
iGMDRD369TGX-1152
iGMDRD60Quinoclamine3
iGMDRD300Tozasertib3
iGMDRD505Pevonedistat2
iGMDRD255SB2250023
iGMDRD77Itraconazole4
iGMDRD318PAC-12
iGMDRD434BMS-5369243
iGMDRD105Triptolide2
iGMDRD221Tamoxifen2
iGMDRD219Bax channel blocker3
iGMDRD499PDMP3
iGMDRD85Ursolic acid2
iGMDRD883CIL55A2
iGMDRD945ML2141
iGMDRD679Bistramide A2
iGMDRD126Tipifarnib4
iGMDRD781Sirolimus3
iGMDRD483SCH-5290743
iGMDRD560MK-22062

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RBPJ

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