TBX22
Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| T-box 22 | MIM:300307 | Ensembl:ENSG00000122145 | HGNC:HGNC:11600 | PA36363 | Xq21.1 |
GO terms in TBX22
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| CC | IDA | GO:0005634 | nucleus |
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IC | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: TBX22
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TBX22
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD84 | Lovastatin acid | 4 |
| iGMDRD307 | Manumycin A | 5 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD82 | Quiflapon | 4 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD772 | BRD4770 | 7 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD318 | PAC-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TBX22
CLASSFICATION
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