GRIA3


Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glutamate ionotropic receptor AMPA type subunit 3MIM:305915Ensembl:ENSG00000125675HGNC:HGNC:4573PA28968Xq25

GO terms in GRIA3


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0001540amyloid-beta binding
MFIBAGO:0004971AMPA glutamate receptor activity
MFIDAGO:0004971AMPA glutamate receptor activity
MFTASGO:0005231excitatory extracellular ligand-gated ion channel activity
MFIEAGO:0005234extracellularly glutamate-gated ion channel activity
BPTASGO:0007215glutamate receptor signaling pathway
BPIEAGO:0034220ion transmembrane transport
BPIEAGO:0035235ionotropic glutamate receptor signaling pathway
BPIEAGO:0060079excitatory postsynaptic potential
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0030054cell junction
CCTASGO:0030666endocytic vesicle membrane
CCIBAGO:0032281AMPA glutamate receptor complex
CCISSGO:0032281AMPA glutamate receptor complex
CCIEAGO:0045211postsynaptic membrane

Gene expression in normal tissue: GRIA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRIA3


DatabasePathway IDPathway Des.
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-399710Activation of AMPA receptors
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-416993Trafficking of GluR2-containing AMPA receptors
reactomeR-HSA-438066Unblocking of NMDA receptor, glutamate binding and activation
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-8849932Synaptic adhesion-like molecules

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD329Merck603
iGMDRD286Nsc 6328398
iGMDRD414MST-3125
iGMDRD871BRD63685
iGMDRD367Ro 28-16753
iGMDRD42Vorinostat2
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib2
iGMDRD552AZD-17754
iGMDRD5Tyrphostin AG 14783
iGMDRD103SN-387
iGMDRD251ML1622
iGMDRD202Curcumin3
iGMDRD481Dactolisib2
iGMDRD68Paclitaxel1
iGMDRD77Itraconazole5
iGMDRD231Importazole5
iGMDRD289Parthenolide1
iGMDRD105Triptolide3
iGMDRD221Tamoxifen1
iGMDRD705Nakiterpiosin6
iGMDRD434BMS-5369245
iGMDRD499PDMP3
iGMDRD351GW843682X2
iGMDRD698Neratinib2
iGMDRD237ABT-7512
iGMDRD341Triacsin c6
iGMDRD435BI-25363
iGMDRD945ML2143
iGMDRD883CIL55A3
iGMDRD123Isoevodiamine8
iGMDRD84Lovastatin acid2
iGMDRD523Cyanoquinoline, 115
iGMDRD701NVP-AUY9226
iGMDRD560MK-22062
iGMDRD345Compound 10b [PMID: 11504634]5
iGMDRD780PP-305
iGMDRD451Serdemetan2
iGMDRD524ISX-93
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine2
iGMDRD260FQI-23
iGMDRD513BML-2594
iGMDRD138PX 122
iGMDRD226ML0065
iGMDRD52Rotenone5
iGMDRD639YK 4-2793
iGMDRD193Fqi12
iGMDRD793BEC (hydrochloride)2
iGMDRD61Kinetin riboside4
iGMDRD2PK-111953
iGMDRD446LY 21832404
iGMDRD797ISOX DUAL2
iGMDRD375GW-4058331
iGMDRD634SCHEMBL26080412
iGMDRD280CYTOCHALASIN B12
iGMDRD599Salermide3
iGMDRD1008SR-II-138A3
iGMDRD126Tipifarnib5
iGMDRD433Lexibulin3
iGMDRD151CHM-13
iGMDRD781Sirolimus3
iGMDRD427ABT7373

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIA3

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