GRIA3
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutamate ionotropic receptor AMPA type subunit 3 | MIM:305915 | Ensembl:ENSG00000125675 | HGNC:HGNC:4573 | PA28968 | Xq25 |
GO terms in GRIA3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001540 | amyloid-beta binding |
| MF | IBA | GO:0004971 | AMPA glutamate receptor activity |
| MF | IDA | GO:0004971 | AMPA glutamate receptor activity |
| MF | TAS | GO:0005231 | excitatory extracellular ligand-gated ion channel activity |
| MF | IEA | GO:0005234 | extracellularly glutamate-gated ion channel activity |
| BP | TAS | GO:0007215 | glutamate receptor signaling pathway |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | IBA | GO:0032281 | AMPA glutamate receptor complex |
| CC | ISS | GO:0032281 | AMPA glutamate receptor complex |
| CC | IEA | GO:0045211 | postsynaptic membrane |
Gene expression in normal tissue: GRIA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIA3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05033 | Nicotine addiction - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-399710 | Activation of AMPA receptors |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors |
| reactome | R-HSA-438066 | Unblocking of NMDA receptor, glutamate binding and activation |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-8849932 | Synaptic adhesion-like molecules |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 8 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD552 | AZD-1775 | 4 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD103 | SN-38 | 7 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD231 | Importazole | 5 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD123 | Isoevodiamine | 8 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 5 |
| iGMDRD701 | NVP-AUY922 | 6 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
| iGMDRD780 | PP-30 | 5 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD226 | ML006 | 5 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD793 | BEC (hydrochloride) | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD2 | PK-11195 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD797 | ISOX DUAL | 2 |
| iGMDRD375 | GW-405833 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 12 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD427 | ABT737 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRIA3
CLASSFICATION
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