RSF1
Summary: This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| remodeling and spacing factor 1 | MIM:608522 | Ensembl:ENSG00000048649 | HGNC:HGNC:18118 | PA29210 | 11q14.1 |
GO terms in RSF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006334 | nucleosome assembly |
| BP | IDA | GO:0006338 | chromatin remodeling |
| BP | IDA | GO:0006352 | DNA-templated transcription, initiation |
| BP | IDA | GO:0016584 | nucleosome positioning |
| BP | TAS | GO:0034080 | CENP-A containing nucleosome assembly |
| BP | IDA | GO:0043392 | negative regulation of DNA binding |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0050434 | positive regulation of viral transcription |
| CC | IBA | GO:0000123 | histone acetyltransferase complex |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IPI | GO:0031213 | RSF complex |
| MF | IBA | GO:0004402 | histone acetyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IBA | GO:0042393 | histone binding |
| MF | IDA | GO:0042393 | histone binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: RSF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RSF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-774815 | Nucleosome assembly |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RSF1
CLASSFICATION
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