RSF1


Summary: This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011].

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OMIM ID
Ensembl ID
HGNC ID
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GO terms in RSF1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006334 nucleosome assembly
BP IDA GO:0006338 chromatin remodeling
BP IDA GO:0006352 DNA-templated transcription, initiation
BP IDA GO:0016584 nucleosome positioning
BP TAS GO:0034080 CENP-A containing nucleosome assembly
BP IDA GO:0043392 negative regulation of DNA binding
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Gene expression in normal tissue: RSF1

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1

Gene-drug pathway distribution

Drug metabolism - cytochrome P4501

Pathways in RSF1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
reactome R-HSA-73886 Chromosome Maintenance
reactome R-HSA-774815 Nucleosome assembly
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD221 Tamoxifen 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RSF1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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