RASGRF2
Summary: RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606614 Ensembl IDEnsembl:ENSG00000113319 HGNC IDHGNC:HGNC:9876 PHARMGKB IDPA34239 Map Location5q14.1 | |||||
GO terms in RASGRF2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005516 | calmodulin binding |
| BP | TAS | GO:0000165 | MAPK cascade |
Gene expression in normal tissue: RASGRF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RASGRF2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| pid | ras_pathway | Regulation of Ras family activation |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RASGRF2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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