CD40LG

Summary: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameCD40 ligand
OMIM IDMIM:300386
Ensembl IDEnsembl:ENSG00000102245
HGNC IDHGNC:HGNC:11935
PHARMGKB IDPA36626
Map LocationXq26.3

GO terms in CD40LG


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006954 inflammatory response
BP NAS GO:0007159 leukocyte cell-cell adhesion
BP IDA GO:0007257 activation of JUN kinase activity
BP IEA GO:0010469 regulation of signaling receptor activity
BP IDA GO:0030168 platelet activation
BP IEA GO:0030183 B cell differentiation
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Gene expression in normal tissue: CD40LG

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 21

Gene-drug pathway distribution

undefined5Proteasome1Drug metabolism - cytochrome P4501Apoptosis regulation1

Pathways in CD40LG


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Database
Pathway ID
Pathway Des.
pid cd40_pathway CD40/CD40L signaling
pid il4_2pathway IL4-mediated signaling events
pid integrin2_pathway Beta2 integrin cell surface interactions
pid nfat_tfpathway Calcineurin-regulated NFAT-dependent transcription in lymphocytes
pid tcrcalciumpathway Calcium signaling in the CD4+ TCR pathway
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD441 TW 37 3
iGMDRD6 AM-580 3
iGMDRD221 Tamoxifen 3
iGMDRD427 ABT737 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD40LG

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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