CD40LG
Summary: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD40 ligand | MIM:300386 | Ensembl:ENSG00000102245 | HGNC:HGNC:11935 | PA36626 | Xq26.3 |
GO terms in CD40LG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006954 | inflammatory response |
| BP | NAS | GO:0007159 | leukocyte cell-cell adhesion |
| BP | IDA | GO:0007257 | activation of JUN kinase activity |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0030168 | platelet activation |
| BP | IEA | GO:0030183 | B cell differentiation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IDA | GO:0032733 | positive regulation of interleukin-10 production |
| BP | IDA | GO:0032735 | positive regulation of interleukin-12 production |
| BP | IDA | GO:0032753 | positive regulation of interleukin-4 production |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IDA | GO:0042100 | B cell proliferation |
| BP | IDA | GO:0042102 | positive regulation of T cell proliferation |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0045190 | isotype switching |
| BP | IEA | GO:0048305 | immunoglobulin secretion |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | IEA | GO:0051023 | regulation of immunoglobulin secretion |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | NAS | GO:0016021 | integral component of membrane |
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IEA | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IPI | GO:0005174 | CD40 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: CD40LG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD40LG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | integrin2_pathway | Beta2 integrin cell surface interactions |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05310 | Asthma - Homo sapiens (human) |
| kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| kegg | hsa05330 | Allograft rejection - Homo sapiens (human) |
| kegg | hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP453 | Inflammatory Response Pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| biocarta | cd40pathway | cd40l signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD441 | TW 37 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD67 | PENFLURIDOL | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD40LG
CLASSFICATION
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