MAP3K9
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 9 | MIM:600136 | Ensembl:ENSG00000006432 | HGNC:HGNC:6861 | PA30607 | 14q24.2 |
GO terms in MAP3K9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ND | GO:0005575 | cellular_component |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007256 | activation of JNKK activity |
| BP | IBA | GO:0007257 | activation of JUN kinase activity |
| BP | ISS | GO:0007257 | activation of JUN kinase activity |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004706 | JUN kinase kinase kinase activity |
| MF | ISS | GO:0004706 | JUN kinase kinase kinase activity |
| MF | NAS | GO:0004708 | MAP kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: MAP3K9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD780 | PP-30 | 10 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD427 | ABT737 | 8 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD267 | Oligomycin A | 5 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD307 | Manumycin A | 4 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD405 | PIK-75 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K9
CLASSFICATION
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