TNFRSF8
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 8 | MIM:153243 | Ensembl:ENSG00000120949 | HGNC:HGNC:11923 | PA36616 | 1p36.22 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TNFRSF8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IDA | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0045556 | positive regulation of TRAIL biosynthetic process |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
Gene expression in normal tissue: TNFRSF8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| netpath | Pathway_TNFalpha | TNFalpha |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD67 | PENFLURIDOL | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD105 | Triptolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF8
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.