TNFRSF8
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:153243 Ensembl IDEnsembl:ENSG00000120949 HGNC IDHGNC:HGNC:11923 PHARMGKB IDPA36616 Map Location1p36.22 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in TNFRSF8
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IDA | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0045556 | positive regulation of TRAIL biosynthetic process |
Gene expression in normal tissue: TNFRSF8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF8
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| netpath | Pathway_TNFalpha | TNFalpha |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF8
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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