ITGAV
Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit alpha V | MIM:193210 | Ensembl:ENSG00000138448 | HGNC:HGNC:6150 | PA37336 | 2q32.1 |
GO terms in ITGAV
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0008305 | integrin complex |
| CC | NAS | GO:0008305 | integrin complex |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | ISS | GO:0009986 | cell surface |
| CC | ISS | GO:0016020 | membrane |
| CC | IDA | GO:0031258 | lamellipodium membrane |
| CC | IDA | GO:0031527 | filopodium membrane |
| CC | IDA | GO:0031528 | microvillus membrane |
| CC | IDA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0034683 | integrin alphav-beta3 complex |
| CC | IDA | GO:0034684 | integrin alphav-beta5 complex |
| CC | IEA | GO:0034685 | integrin alphav-beta6 complex |
| CC | IDA | GO:0034686 | integrin alphav-beta8 complex |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | NAS | GO:0035866 | alphav-beta3 integrin-PKCalpha complex |
| CC | IDA | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex |
| CC | IDA | GO:0035868 | alphav-beta3 integrin-HMGB1 complex |
| CC | TAS | GO:0045335 | phagocytic vesicle |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEP | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | TAS | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| BP | IDA | GO:0007155 | cell adhesion |
| BP | IMP | GO:0007160 | cell-matrix adhesion |
| BP | NAS | GO:0007160 | cell-matrix adhesion |
| BP | IEA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | NAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0010745 | negative regulation of macrophage derived foam cell differentiation |
| BP | IMP | GO:0010888 | negative regulation of lipid storage |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0031589 | cell-substrate adhesion |
| BP | IMP | GO:0032369 | negative regulation of lipid transport |
| BP | IDA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IEA | GO:0033690 | positive regulation of osteoblast proliferation |
| BP | IMP | GO:0034113 | heterotypic cell-cell adhesion |
| BP | IDA | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IMP | GO:0035987 | endodermal cell differentiation |
| BP | IMP | GO:0038027 | apolipoprotein A-I-mediated signaling pathway |
| BP | IEA | GO:0038044 | transforming growth factor-beta secretion |
| BP | IGI | GO:0043277 | apoptotic cell clearance |
| BP | ISS | GO:0043277 | apoptotic cell clearance |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process |
| BP | IDA | GO:0045785 | positive regulation of cell adhesion |
| BP | IMP | GO:0046718 | viral entry into host cell |
| BP | TAS | GO:0046718 | viral entry into host cell |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0050748 | negative regulation of lipoprotein metabolic process |
| BP | IDA | GO:0050764 | regulation of phagocytosis |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0050919 | negative chemotaxis |
| BP | NAS | GO:0052066 | entry of symbiont into host cell by promotion of host phagocytosis |
| BP | ISS | GO:0070371 | ERK1 and ERK2 cascade |
| BP | IDA | GO:0070588 | calcium ion transmembrane transport |
| BP | ISS | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IDA | GO:2000536 | negative regulation of entry of bacterium into host cell |
| BP | IMP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | ISS | GO:0001846 | opsonin binding |
| MF | IDA | GO:0001968 | fibronectin binding |
| MF | IDA | GO:0002020 | protease binding |
| MF | ISS | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005178 | integrin binding |
| MF | IDA | GO:0005245 | voltage-gated calcium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015026 | coreceptor activity |
| MF | IDA | GO:0017134 | fibroblast growth factor binding |
| MF | IDA | GO:0019960 | C-X3-C chemokine binding |
| MF | IDA | GO:0031994 | insulin-like growth factor I binding |
| MF | IDA | GO:0038132 | neuregulin binding |
| MF | IEA | GO:0042277 | peptide binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | ISS | GO:0050431 | transforming growth factor beta binding |
| MF | IDA | GO:0050840 | extracellular matrix binding |
| MF | IDA | GO:1990430 | extracellular matrix protein binding |
Gene expression in normal tissue: ITGAV
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGAV
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210990 | PECAM1 interactions |
| reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000157 | Laminin interactions |
| reactome | R-HSA-3000170 | Syndecan interactions |
| reactome | R-HSA-3000170 | Syndecan interactions |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-3000178 | ECM proteoglycans |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | integrin5_pathway | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | plexind1_pathway | Plexin-D1 Signaling |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| wikipathways | WP1434 | Osteopontin Signaling |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP322 | Osteoblast Signaling |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD231 | Importazole | 5 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD163 | all trans Retinoic Acid | 2 |
| iGMDRD280 | CYTOCHALASIN B | 7 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD318 | PAC-1 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGAV
CLASSFICATION
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