ITGAV
Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:193210 Ensembl IDEnsembl:ENSG00000138448 HGNC IDHGNC:HGNC:6150 PHARMGKB IDPA37336 Map Location2q32.1 |
GO terms in ITGAV
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005829 | cytosol |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | NAS | GO:0005887 | integral component of plasma membrane |
CC | HDA | GO:0005925 | focal adhesion |
CC | IDA | GO:0005925 | focal adhesion |
Gene expression in normal tissue: ITGAV
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGAV
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) |
reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1280218 | Adaptive Immune System |
reactome | R-HSA-1474244 | Extracellular matrix organization |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ITGAV
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |