ITGAV


Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:193210
PHARMGKB IDPA37336
Map Location2q32.1

GO terms in ITGAV


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005829 cytosol
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC NAS GO:0005887 integral component of plasma membrane
CC HDA GO:0005925 focal adhesion
CC IDA GO:0005925 focal adhesion
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Gene expression in normal tissue: ITGAV

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGAV


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
reactome R-HSA-1236975 Antigen processing-Cross presentation
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1474244 Extracellular matrix organization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD85 Ursolic acid 1
iGMDRD499 PDMP 2
iGMDRD177 Teniposide 2
iGMDRD132 (-)-gallocatechin-3-O-gallate 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGAV

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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