ARHGAP9
Summary: This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho GTPase activating protein 9 | MIM:610576 | Ensembl:ENSG00000123329 | HGNC:HGNC:14130 | PA24962 | 12q13.3 |
GO terms in ARHGAP9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007165 | signal transduction |
| BP | IBA | GO:0043087 | regulation of GTPase activity |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0034774 | secretory granule lumen |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
Gene expression in normal tissue: ARHGAP9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGAP9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD271 | Brefeldin A | 6 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD221 | Tamoxifen | 6 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD188 | Piperlongumine | 7 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD630 | ML203 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD171 | Pemetrexed | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGAP9
CLASSFICATION
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