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NCAM1

Summary: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameneural cell adhesion molecule 1 OMIM IDMIM:116930 Ensembl IDEnsembl:ENSG00000149294 HGNC IDHGNC:HGNC:7656 PHARMGKB IDPA31459 Map Location11q23.2

Gene Categories:

CELL SURFACE EXTERNAL SIDE OF PLASMA MEMBRANE DRUGGABLE GENOME

GO terms in NCAM1

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0000139	Golgi membrane
CC	IDA	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IDA	GO:0009897	external side of plasma membrane
CC	IDA	GO:0009986	cell surface

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Gene expression in normal tissue: NCAM1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NCAM1

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Database	Pathway ID	Pathway Des.
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP2406	Cardiac Progenitor Differentiation
wikipathways	WP3995	Prion disease pathway
pid	fgf_pathway	FGF signaling pathway
kegg	hsa04514	Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegg	hsa05020	Prion diseases - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD126	Tipifarnib	2
iGMDRD889	Compound 7d-cis	2
iGMDRD579	PF750	3
iGMDRD772	BRD4770	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCAM1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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