NCAM1
Summary: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neural cell adhesion molecule 1 | MIM:116930 | Ensembl:ENSG00000149294 | HGNC:HGNC:7656 | PA31459 | 11q23.2 |
GO terms in NCAM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031225 | anchored component of membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | ISS | GO:0071679 | commissural neuron axon guidance |
| BP | ISS | GO:2001260 | regulation of semaphorin-plexin signaling pathway |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
Gene expression in normal tissue: NCAM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCAM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP3995 | Prion disease pathway |
| pid | fgf_pathway | FGF signaling pathway |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-3000178 | ECM proteoglycans |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-419037 | NCAM1 interactions |
| reactome | R-HSA-419037 | NCAM1 interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD193 | Fqi1 | 7 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD522 | ML-030 | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD499 | PDMP | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD177 | Teniposide | 5 |
| iGMDRD883 | CIL55A | 4 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD221 | Tamoxifen | 4 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD263 | AACOCF3 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCAM1
CLASSFICATION
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