SEARCH

HOME / SEARCH / PIK3R4

PIK3R4

Summary:

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
phosphoinositide-3-kinase regulatory subunit 4	MIM:602610	Ensembl:ENSG00000196455	HGNC:HGNC:8982	PA33315	3q22.1

Gene Categories:

LIPID KINASE DRUGGABLE GENOME TUMOR SUPPRESSOR PHOSPHATIDYLINOSITOL 3 KINASE KINASE SERINE THREONINE KINASE

GO terms in PIK3R4

Term Type	Evidence Type	GO Term ID	GO Des.
MF	NAS	GO:0004672	protein kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	TAS	GO:0016303	1-phosphatidylinositol-3-kinase activity
CC	IBA	GO:0005643	nuclear pore
CC	IBA	GO:0005770	late endosome
CC	IDA	GO:0005770	late endosome
CC	IEA	GO:0005776	autophagosome
CC	TAS	GO:0005829	cytosol
CC	ISS	GO:0005930	axoneme
CC	IDA	GO:0015630	microtubule cytoskeleton
CC	HDA	GO:0016020	membrane
CC	TAS	GO:0030670	phagocytic vesicle membrane
CC	IBA	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I
CC	IBA	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II
CC	ISS	GO:0035032	phosphatidylinositol 3-kinase complex, class III
CC	IDA	GO:0043231	intracellular membrane-bounded organelle
CC	IBA	GO:0071561	nucleus-vacuole junction
BP	IBA	GO:0006468	protein phosphorylation
BP	NAS	GO:0006468	protein phosphorylation
BP	IBA	GO:0006623	protein targeting to vacuole
BP	IBA	GO:0016236	macroautophagy
BP	TAS	GO:0016236	macroautophagy
BP	IBA	GO:0030242	autophagy of peroxisome
BP	IMP	GO:0032465	regulation of cytokinesis
BP	IMP	GO:0032801	receptor catabolic process
BP	TAS	GO:0034162	toll-like receptor 9 signaling pathway
BP	IEA	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
BP	ISS	GO:0042149	cellular response to glucose starvation
BP	IDA	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
BP	IBA	GO:0045324	late endosome to vacuole transport

Gene expression in normal tissue: PIK3R4

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3R4

Database	Pathway ID	Pathway Des.
humancyc	PWY-6352	3-phosphoinositide biosynthesis
humancyc	PWY-6371	superpathway of inositol phosphate compounds
kegg	hsa04136	Autophagy - other - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa04371	Apelin signaling pathway - Homo sapiens (human)
smpdb	SMP00011	Inositol Metabolism
smpdb	SMP00463	Phosphatidylinositol Phosphate Metabolism
smpdb	SMP00582	Joubert syndrome
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP481	Insulin Signaling
wikipathways	WP51	Regulation of Actin Cytoskeleton
wikipathways	WP710	DNA Damage Response (only ATM dependent)
reactome	R-HSA-109704	PI3K Cascade
reactome	R-HSA-112399	IRS-mediated signalling
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1483255	PI Metabolism
reactome	R-HSA-1483257	Phospholipid metabolism
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1632852	Macroautophagy
reactome	R-HSA-1660514	Synthesis of PIPs at the Golgi membrane
reactome	R-HSA-1660516	Synthesis of PIPs at the early endosome membrane
reactome	R-HSA-1660517	Synthesis of PIPs at the late endosome membrane
reactome	R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168898	Toll-Like Receptors Cascades
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactome	R-HSA-2428924	IGF1R signaling cascade
reactome	R-HSA-2428928	IRS-related events triggered by IGF1R
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-5668599	RHO GTPases Activate NADPH Oxidases
reactome	R-HSA-74751	Insulin receptor signalling cascade
reactome	R-HSA-74752	Signaling by Insulin receptor
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD394	BX-795	1
iGMDRD193	Fqi1	3
iGMDRD61	Kinetin riboside	2
iGMDRD446	LY 2183240	1
iGMDRD483	SCH-529074	2
iGMDRD781	Sirolimus	2
iGMDRD144	NSC95397	2
iGMDRD779	PRL-3 Inhibitor I	2
iGMDRD427	ABT737	2
iGMDRD599	Salermide	1
iGMDRD579	PF750	2
iGMDRD126	Tipifarnib	2
iGMDRD554	CHEMBL1434137	3
iGMDRD433	Lexibulin	2
iGMDRD151	CHM-1	2
iGMDRD356	PNU-74654	1
iGMDRD64	Parbendazole	3
iGMDRD506	Fedratinib	1
iGMDRD888	Compound 44	2
iGMDRD562	Navitoclax	2
iGMDRD441	TW 37	2
iGMDRD870	BRD63610	1
iGMDRD52	Rotenone	4
iGMDRD260	FQI-2	2
iGMDRD255	SB225002	2
iGMDRD883	CIL55A	2
iGMDRD945	ML214	1
iGMDRD901	ELCPK	2
iGMDRD123	Isoevodiamine	2
iGMDRD499	PDMP	2
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD237	ABT-751	7
iGMDRD424	Tamatinib	2
iGMDRD300	Tozasertib	2
iGMDRD147	Prima-1	1
iGMDRD329	Merck60	1
iGMDRD366	PI-103	3
iGMDRD67	PENFLURIDOL	5
iGMDRD77	Itraconazole	2
iGMDRD6	AM-580	5
iGMDRD105	Triptolide	2
iGMDRD289	Parthenolide	2
iGMDRD221	Tamoxifen	2
iGMDRD137	Indisulam	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3R4

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.