CTSS
Summary: The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cathepsin S | MIM:116845 | Ensembl:ENSG00000163131 | HGNC:HGNC:2545 | PA27041 | 1q21.3 |
GO terms in CTSS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005764 | lysosome |
| CC | IDA | GO:0005764 | lysosome |
| CC | TAS | GO:0036021 | endolysosome lumen |
| CC | TAS | GO:0043202 | lysosomal lumen |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | TAS | GO:1904724 | tertiary granule lumen |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | IEP | GO:0002250 | adaptive immune response |
| BP | IDA | GO:0006508 | proteolysis |
| BP | TAS | GO:0006955 | immune response |
| BP | IDA | GO:0010447 | response to acidic pH |
| BP | IDA | GO:0016485 | protein processing |
| BP | TAS | GO:0019882 | antigen processing and presentation |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | IDA | GO:0030574 | collagen catabolic process |
| BP | IDA | GO:0034769 | basement membrane disassembly |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0048002 | antigen processing and presentation of peptide antigen |
| BP | IBA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | IDA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | IEP | GO:0097067 | cellular response to thyroid hormone stimulus |
| BP | IDA | GO:2001259 | positive regulation of cation channel activity |
| MF | IPI | GO:0001968 | fibronectin binding |
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IDA | GO:0005518 | collagen binding |
| MF | IDA | GO:0043236 | laminin binding |
| MF | IPI | GO:0043394 | proteoglycan binding |
Gene expression in normal tissue: CTSS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTSS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236977 | Endosomal/Vacuolar pathway |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 7 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD718 | Pyrvinium pamoate | 4 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD889 | Compound 7d-cis | 8 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD82 | Quiflapon | 4 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD286 | Nsc 632839 | 8 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD221 | Tamoxifen | 6 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD499 | PDMP | 4 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD307 | Manumycin A | 4 |
| iGMDRD84 | Lovastatin acid | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTSS
CLASSFICATION
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