CTSS

Summary: The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecathepsin S
OMIM IDMIM:116845
Ensembl IDEnsembl:ENSG00000163131
HGNC IDHGNC:HGNC:2545
PHARMGKB IDPA27041
Map Location1q21.3

GO terms in CTSS


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Term Type
Evidence Type
GO Term ID
GO Des.
CC NAS GO:0005576 extracellular region
CC TAS GO:0005576 extracellular region
CC HDA GO:0005615 extracellular space
CC IBA GO:0005615 extracellular space
CC IDA GO:0005615 extracellular space
CC IBA GO:0005764 lysosome
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Gene expression in normal tissue: CTSS

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 45undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 36BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 33BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6

Gene-drug pathway distribution

undefined24Apoptosis regulation3Stilbenoid, diarylheptanoid and gingerol biosynthesis1Genome integrity1Drug metabolism - cytochrome P4501IGFR signaling1ERK MAPK signaling1Longevity regulating pathway1Mitosis1

Pathways in CTSS


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1236975 Antigen processing-Cross presentation
reactome R-HSA-1236977 Endosomal/Vacuolar pathway
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1474228 Degradation of the extracellular matrix
reactome R-HSA-1474228 Degradation of the extracellular matrix
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD524 ISX-9 3
iGMDRD398 Sepantronium 3
iGMDRD562 Navitoclax 7
iGMDRD577 BIX01294 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTSS

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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