TNFRSF18
Summary: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603905 Ensembl IDEnsembl:ENSG00000186891 HGNC IDHGNC:HGNC:11914 PHARMGKB IDPA36607 Map Location1p36.33 | |||||
GO terms in TNFRSF18
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | IMP | GO:0002687 | positive regulation of leukocyte migration |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
Gene expression in normal tissue: TNFRSF18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF18
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4079 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF18
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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