TNFRSF18
Summary: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 18 | MIM:603905 | Ensembl:ENSG00000186891 | HGNC:HGNC:11914 | PA36607 | 1p36.33 |
GO terms in TNFRSF18
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | IMP | GO:0002687 | positive regulation of leukocyte migration |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0045589 | regulation of regulatory T cell differentiation |
| BP | IMP | GO:0045785 | positive regulation of cell adhesion |
| CC | IEA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: TNFRSF18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF18
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4079 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 12 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD652 | UNC0638 | 4 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD375 | GW-405833 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD802 | 4-methylfasudil | 6 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD300 | Tozasertib | 7 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD100 | Zebularine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF18
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