WNK1


Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
WNK lysine deficient protein kinase 1MIM:605232Ensembl:ENSG00000060237HGNC:HGNC:14540PA3378212p13.33

GO terms in WNK1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFIMPGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIDAGO:0019869chloride channel inhibitor activity
MFIEAGO:0019870potassium channel inhibitor activity
MFIPIGO:0019901protein kinase binding
MFIDAGO:0019902phosphatase binding
MFIEAGO:0030291protein serine/threonine kinase inhibitor activity
MFIMPGO:0030295protein kinase activator activity
BPISSGO:0002028regulation of sodium ion transport
BPIEAGO:0003084positive regulation of systemic arterial blood pressure
BPIBAGO:0006468protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006468protein phosphorylation
BPISSGO:0006811ion transport
BPIDAGO:0010923negative regulation of phosphatase activity
BPTASGO:0018107peptidyl-threonine phosphorylation
BPIDAGO:0023016signal transduction by trans-phosphorylation
BPIEAGO:0032147activation of protein kinase activity
BPIBAGO:0032414positive regulation of ion transmembrane transporter activity
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPTASGO:0035556intracellular signal transduction
BPIEAGO:0046777protein autophosphorylation
BPNASGO:0048666neuron development
BPISSGO:0050794regulation of cellular process
BPIEAGO:0071277cellular response to calcium ion
BPIEAGO:0071901negative regulation of protein serine/threonine kinase activity
BPIEAGO:0090188negative regulation of pancreatic juice secretion
BPIMPGO:0090263positive regulation of canonical Wnt signaling pathway
CCIDAGO:0005737cytoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCISSGO:0005829cytosol
CCISSGO:0016020membrane

Gene expression in normal tissue: WNK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WNK1


DatabasePathway IDPathway Des.
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-983712Ion channel transport
pharmgkbPA165984799Diuretics Pathway, Pharmacodynamics

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD267Oligomycin A3
iGMDRD434BMS-5369242
iGMDRD746CDK9 Inhibitor1
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A1
iGMDRD246NPC265
iGMDRD414MST-3122
iGMDRD652UNC06384
iGMDRD116CD4371
iGMDRD424Tamatinib2
iGMDRD512nutlin 34
iGMDRD486Tosedostat2
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD177Teniposide2
iGMDRD351GW843682X4
iGMDRD885Compound 1102
iGMDRD870BRD636101
iGMDRD255SB2250023
iGMDRD8024-methylfasudil3
iGMDRD138PX 122
iGMDRD60Quinoclamine2
iGMDRD577BIX012941
iGMDRD494Neopeltolide1
iGMDRD772BRD47705
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B2
iGMDRD193Fqi14
iGMDRD446LY 21832402
iGMDRD77Itraconazole3
iGMDRD105Triptolide3
iGMDRD221Tamoxifen1
iGMDRD705Nakiterpiosin7
iGMDRD5Tyrphostin AG 14785
iGMDRD121GMX17781
iGMDRD137Indisulam3
iGMDRD158NSC1415405
iGMDRD202Curcumin7
iGMDRD552AZD-17752
iGMDRD263AACOCF32
iGMDRD366PI-1034
iGMDRD286Nsc 6328392
iGMDRD871BRD63681
iGMDRD523Cyanoquinoline, 113
iGMDRD405PIK-752
iGMDRD583LDN 1931891
iGMDRD584VER 1550082
iGMDRD511CHEMBL3993792
iGMDRD154NSC237666
iGMDRD123Isoevodiamine4
iGMDRD237ABT-7511
iGMDRD294Batimastat5
iGMDRD187BRD98765
iGMDRD171Pemetrexed6
iGMDRD260FQI-21
iGMDRD474Avrainvillamide2
iGMDRD64Parbendazole4
iGMDRD888Compound 442
iGMDRD506Fedratinib10
iGMDRD188Piperlongumine5
iGMDRD74Idarubicin2
iGMDRD399Selumetinib3
iGMDRD483SCH-5290745
iGMDRD670ML 2102
iGMDRD779PRL-3 Inhibitor I1
iGMDRD546BMS-7548073
iGMDRD420Leucascandrolide A1
iGMDRD749ZINC67184531
iGMDRD425ERASTIN4
iGMDRD126Tipifarnib1
iGMDRD151CHM-12
iGMDRD466Chaetocin1
iGMDRD61Kinetin riboside3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WNK1

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