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WNK1

Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
WNK lysine deficient protein kinase 1	MIM:605232	Ensembl:ENSG00000060237	HGNC:HGNC:14540	PA33782	12p13.33

Gene Categories:

ION CHANNEL SERINE THREONINE KINASE KINASE TRANSPORTER TYROSINE KINASE DRUGGABLE GENOME

GO terms in WNK1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0000287	magnesium ion binding
MF	IMP	GO:0004672	protein kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005524	ATP binding
MF	IDA	GO:0019869	chloride channel inhibitor activity
MF	IEA	GO:0019870	potassium channel inhibitor activity
MF	IPI	GO:0019901	protein kinase binding
MF	IDA	GO:0019902	phosphatase binding
MF	IEA	GO:0030291	protein serine/threonine kinase inhibitor activity
MF	IMP	GO:0030295	protein kinase activator activity
BP	ISS	GO:0002028	regulation of sodium ion transport
BP	IEA	GO:0003084	positive regulation of systemic arterial blood pressure
BP	IBA	GO:0006468	protein phosphorylation
BP	IDA	GO:0006468	protein phosphorylation
BP	IMP	GO:0006468	protein phosphorylation
BP	ISS	GO:0006811	ion transport
BP	IDA	GO:0010923	negative regulation of phosphatase activity
BP	TAS	GO:0018107	peptidyl-threonine phosphorylation
BP	IDA	GO:0023016	signal transduction by trans-phosphorylation
BP	IEA	GO:0032147	activation of protein kinase activity
BP	IBA	GO:0032414	positive regulation of ion transmembrane transporter activity
BP	IBA	GO:0035556	intracellular signal transduction
BP	IDA	GO:0035556	intracellular signal transduction
BP	TAS	GO:0035556	intracellular signal transduction
BP	IEA	GO:0046777	protein autophosphorylation
BP	NAS	GO:0048666	neuron development
BP	ISS	GO:0050794	regulation of cellular process
BP	IEA	GO:0071277	cellular response to calcium ion
BP	IEA	GO:0071901	negative regulation of protein serine/threonine kinase activity
BP	IEA	GO:0090188	negative regulation of pancreatic juice secretion
BP	IMP	GO:0090263	positive regulation of canonical Wnt signaling pathway
CC	IDA	GO:0005737	cytoplasm
CC	IBA	GO:0005829	cytosol
CC	IDA	GO:0005829	cytosol
CC	ISS	GO:0005829	cytosol
CC	ISS	GO:0016020	membrane

Gene expression in normal tissue: WNK1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WNK1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-2672351	Stimuli-sensing channels
reactome	R-HSA-382551	Transport of small molecules
reactome	R-HSA-983712	Ion channel transport
pharmgkb	PA165984799	Diuretics Pathway, Pharmacodynamics

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD267	Oligomycin A	3
iGMDRD434	BMS-536924	2
iGMDRD746	CDK9 Inhibitor	1
iGMDRD505	Pevonedistat	3
iGMDRD886	Compound 1541A	1
iGMDRD246	NPC26	5
iGMDRD414	MST-312	2
iGMDRD652	UNC0638	4
iGMDRD116	CD437	1
iGMDRD424	Tamatinib	2
iGMDRD512	nutlin 3	4
iGMDRD486	Tosedostat	2
iGMDRD132	(-)-gallocatechin-3-O-gallate	2
iGMDRD177	Teniposide	2
iGMDRD351	GW843682X	4
iGMDRD885	Compound 110	2
iGMDRD870	BRD63610	1
iGMDRD255	SB225002	3
iGMDRD802	4-methylfasudil	3
iGMDRD138	PX 12	2
iGMDRD60	Quinoclamine	2
iGMDRD577	BIX01294	1
iGMDRD494	Neopeltolide	1
iGMDRD772	BRD4770	5
iGMDRD297	Austocystin D	2
iGMDRD280	CYTOCHALASIN B	2
iGMDRD193	Fqi1	4
iGMDRD446	LY 2183240	2
iGMDRD77	Itraconazole	3
iGMDRD105	Triptolide	3
iGMDRD221	Tamoxifen	1
iGMDRD705	Nakiterpiosin	7
iGMDRD5	Tyrphostin AG 1478	5
iGMDRD121	GMX1778	1
iGMDRD137	Indisulam	3
iGMDRD158	NSC141540	5
iGMDRD202	Curcumin	7
iGMDRD552	AZD-1775	2
iGMDRD263	AACOCF3	2
iGMDRD366	PI-103	4
iGMDRD286	Nsc 632839	2
iGMDRD871	BRD6368	1
iGMDRD523	Cyanoquinoline, 11	3
iGMDRD405	PIK-75	2
iGMDRD583	LDN 193189	1
iGMDRD584	VER 155008	2
iGMDRD511	CHEMBL399379	2
iGMDRD154	NSC23766	6
iGMDRD123	Isoevodiamine	4
iGMDRD237	ABT-751	1
iGMDRD294	Batimastat	5
iGMDRD187	BRD9876	5
iGMDRD171	Pemetrexed	6
iGMDRD260	FQI-2	1
iGMDRD474	Avrainvillamide	2
iGMDRD64	Parbendazole	4
iGMDRD888	Compound 44	2
iGMDRD506	Fedratinib	10
iGMDRD188	Piperlongumine	5
iGMDRD74	Idarubicin	2
iGMDRD399	Selumetinib	3
iGMDRD483	SCH-529074	5
iGMDRD670	ML 210	2
iGMDRD779	PRL-3 Inhibitor I	1
iGMDRD546	BMS-754807	3
iGMDRD420	Leucascandrolide A	1
iGMDRD749	ZINC6718453	1
iGMDRD425	ERASTIN	4
iGMDRD126	Tipifarnib	1
iGMDRD151	CHM-1	2
iGMDRD466	Chaetocin	1
iGMDRD61	Kinetin riboside	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WNK1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.