STK24
Summary: This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 24 | MIM:604984 | Ensembl:ENSG00000102572 | HGNC:HGNC:11403 | PA36210 | 13q32.2 |
GO terms in STK24
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016020 | membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| BP | IMP | GO:0009267 | cellular response to starvation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IMP | GO:0030336 | negative regulation of cell migration |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0042542 | response to hydrogen peroxide |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0048679 | regulation of axon regeneration |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | IMP | GO:0097194 | execution phase of apoptosis |
| BP | TAS | GO:0097194 | execution phase of apoptosis |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: STK24
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK24
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-75153 | Apoptotic execution phase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 22 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD394 | BX-795 | 5 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD474 | Avrainvillamide | 8 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD84 | Lovastatin acid | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD150 | RITA | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD231 | Importazole | 4 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD329 | Merck60 | 10 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD505 | Pevonedistat | 8 |
| iGMDRD886 | Compound 1541A | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK24
CLASSFICATION
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