AKAP6
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:604691 Ensembl IDEnsembl:ENSG00000151320 HGNC IDHGNC:HGNC:376 PHARMGKB IDPA24670 Map Location14q12 |
GO terms in AKAP6
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IC | GO:0001508 | action potential |
BP | NAS | GO:0006605 | protein targeting |
BP | ISS | GO:0010738 | regulation of protein kinase A signaling |
BP | IC | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
BP | NAS | GO:0019933 | cAMP-mediated signaling |
BP | ISS | GO:0030307 | positive regulation of cell growth |
Gene expression in normal tissue: AKAP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKAP6
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP35 | G Protein Signaling Pathways |
Showing 1 to 1 of 1 rows
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in AKAP6
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |