AKAP6


Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:604691
PHARMGKB IDPA24670
Map Location14q12

GO terms in AKAP6


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IC GO:0001508 action potential
BP NAS GO:0006605 protein targeting
BP ISS GO:0010738 regulation of protein kinase A signaling
BP IC GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
BP NAS GO:0019933 cAMP-mediated signaling
BP ISS GO:0030307 positive regulation of cell growth
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Gene expression in normal tissue: AKAP6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKAP6


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Database
Pathway ID
Pathway Des.
wikipathways WP35 G Protein Signaling Pathways
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 4
iGMDRD870 BRD63610 3
iGMDRD318 PAC-1 3
iGMDRD782 DC-45-A2 9
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKAP6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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