STAC2

Summary: This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSH3 and cysteine rich domain 2
OMIM ID
Ensembl IDEnsembl:ENSG00000141750
HGNC IDHGNC:HGNC:23990
PHARMGKB IDPA134939947
Map Location17q12

GO terms in STAC2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IEA GO:0046872 metal ion binding
BP IEA GO:0035556 intracellular signal transduction
BP ISS GO:1901387 positive regulation of voltage-gated calcium channel activity
BP ISS GO:1903078 positive regulation of protein localization to plasma membrane
CC IEA GO:0005829 cytosol
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Gene expression in normal tissue: STAC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined25Cell cycle2Purine metabolism1ERK MAPK signaling1Drug metabolism - cytochrome P4501Other, kinases1

Pathways in STAC2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD705 Nakiterpiosin 3
iGMDRD221 Tamoxifen 3
iGMDRD434 BMS-536924 5
iGMDRD885 Compound 110 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAC2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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