STAC2


Summary: This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SH3 and cysteine rich domain 2Ensembl:ENSG00000141750HGNC:HGNC:23990PA13493994717q12

GO terms in STAC2


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0035556intracellular signal transduction
BPISSGO:1901387positive regulation of voltage-gated calcium channel activity
BPISSGO:1903078positive regulation of protein localization to plasma membrane
CCIEAGO:0005829cytosol
CCISSGO:0031234extrinsic component of cytoplasmic side of plasma membrane

Gene expression in normal tissue: STAC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STAC2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD705Nakiterpiosin3
iGMDRD221Tamoxifen3
iGMDRD434BMS-5369245
iGMDRD885Compound 1103
iGMDRD77Itraconazole2
iGMDRD8024-methylfasudil3
iGMDRD886Compound 1541A1
iGMDRD505Pevonedistat3
iGMDRD552AZD-17756
iGMDRD60Quinoclamine1
iGMDRD353PD03259011
iGMDRD871BRD63681
iGMDRD887Compound 23 citrate3
iGMDRD872BRD71375
iGMDRD329Merck602
iGMDRD577BIX012942
iGMDRD506Fedratinib8
iGMDRD269Purmorphamine3
iGMDRD116CD4373
iGMDRD79Gemcitabine6
iGMDRD126Tipifarnib1
iGMDRD579PF7503
iGMDRD280CYTOCHALASIN B1
iGMDRD375GW-4058336
iGMDRD154NSC237661
iGMDRD435BI-25364
iGMDRD446LY 21832401
iGMDRD341Triacsin c1
iGMDRD201SKI II3
iGMDRD351GW843682X3
iGMDRD237ABT-7513

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAC2

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