STAC2
Summary: This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SH3 and cysteine rich domain 2 | Ensembl:ENSG00000141750 | HGNC:HGNC:23990 | PA134939947 | 17q12 |
GO terms in STAC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:1901387 | positive regulation of voltage-gated calcium channel activity |
| BP | ISS | GO:1903078 | positive regulation of protein localization to plasma membrane |
| CC | IEA | GO:0005829 | cytosol |
| CC | ISS | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
Gene expression in normal tissue: STAC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAC2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD552 | AZD-1775 | 6 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 8 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD79 | Gemcitabine | 6 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD375 | GW-405833 | 6 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD435 | BI-2536 | 4 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAC2
CLASSFICATION
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