ITPR2


Summary: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
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GO terms in ITPR2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0001666 response to hypoxia
BP TAS GO:0007165 signal transduction
BP TAS GO:0030168 platelet activation
BP IEA GO:0048016 inositol phosphate-mediated signaling
BP TAS GO:0050796 regulation of insulin secretion
BP IBA GO:0051209 release of sequestered calcium ion into cytosol
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Gene expression in normal tissue: ITPR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITPR2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-111885 Opioid Signalling
reactome R-HSA-112040 G-protein mediated events
reactome R-HSA-112043 PLC beta mediated events
reactome R-HSA-114508 Effects of PIP2 hydrolysis
reactome R-HSA-1280218 Adaptive Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD193 Fqi1 2
iGMDRD201 SKI II 4
iGMDRD446 LY 2183240 2
iGMDRD375 GW-405833 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITPR2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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