ITPR2
Summary: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inositol 1,4,5-trisphosphate receptor type 2 | MIM:600144 | Ensembl:ENSG00000123104 | HGNC:HGNC:6181 | PA29979 | 12p11.23 |
GO terms in ITPR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0048016 | inositol phosphate-mediated signaling |
| BP | TAS | GO:0050796 | regulation of insulin secretion |
| BP | IBA | GO:0051209 | release of sequestered calcium ion into cytosol |
| BP | ISS | GO:0051209 | release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0071320 | cellular response to cAMP |
| BP | IEA | GO:0071361 | cellular response to ethanol |
| BP | TAS | GO:1903779 | regulation of cardiac conduction |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005938 | cell cortex |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0016529 | sarcoplasmic reticulum |
| CC | IBA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IBA | GO:0030667 | secretory granule membrane |
| CC | TAS | GO:0031095 | platelet dense tubular network membrane |
| CC | IMP | GO:0033017 | sarcoplasmic reticulum membrane |
| CC | IDA | GO:0043235 | receptor complex |
| MF | IBA | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| MF | ISS | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| MF | IBA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015085 | calcium ion transmembrane transporter activity |
| MF | IBA | GO:0035091 | phosphatidylinositol binding |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
| MF | IBA | GO:0070679 | inositol 1,4,5 trisphosphate binding |
| MF | IEA | GO:0070679 | inositol 1,4,5 trisphosphate binding |
| MF | IPI | GO:0097110 | scaffold protein binding |
Gene expression in normal tissue: ITPR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITPR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-139853 | Elevation of cytosolic Ca2+ levels |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418360 | Platelet calcium homeostasis |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5578775 | Ion homeostasis |
| reactome | R-HSA-5578775 | Ion homeostasis |
| reactome | R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| netpath | Pathway_BCR | BCR |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD201 | SKI II | 4 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD1008 | SR-II-138A | 7 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD483 | SCH-529074 | 4 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 9 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD497 | 16beta-Bromoandrosterone | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD150 | RITA | 2 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD221 | Tamoxifen | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITPR2
CLASSFICATION
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