TNFRSF4

Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameTNF receptor superfamily member 4
OMIM IDMIM:600315
Ensembl IDEnsembl:ENSG00000186827
HGNC IDHGNC:HGNC:11918
PHARMGKB IDPA36611
Map Location1p36.33

GO terms in TNFRSF4


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001618 virus receptor activity
MF TAS GO:0005031 tumor necrosis factor-activated receptor activity
MF IPI GO:0005515 protein binding
BP TAS GO:0006955 immune response
BP ISS GO:0030890 positive regulation of B cell proliferation
BP TAS GO:0033209 tumor necrosis factor-mediated signaling pathway
Showing 1 to 6 of 14 rows rows per page

Gene expression in normal tissue: TNFRSF4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 68undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 4LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 36BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1

Gene-drug pathway distribution

undefined17Drug metabolism - cytochrome P4501Mitosis1Chromatin histone methylation1Purine metabolism1Longevity regulating pathway1

Pathways in TNFRSF4


Loading, please wait...
Database
Pathway ID
Pathway Des.
pid cd8tcrdownstreampathway Downstream signaling in naïve CD8+ T cells
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-168256 Immune System
reactome R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
reactome R-HSA-5669034 TNFs bind their physiological receptors
Showing 1 to 6 of 6 rows

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD201 SKI II 5
iGMDRD375 GW-405833 9
iGMDRD634 SCHEMBL2608041 2
iGMDRD154 NSC23766 5
Showing 1 to 4 of 22 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF4

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.