UBE2O
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin conjugating enzyme E2 O | MIM:617649 | Ensembl:ENSG00000175931 | HGNC:HGNC:29554 | PA142670651 | 17q25.1 |
GO terms in UBE2O
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
| MF | IBA | GO:0061631 | ubiquitin conjugating enzyme activity |
| MF | IDA | GO:0061631 | ubiquitin conjugating enzyme activity |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| BP | IDA | GO:0006513 | protein monoubiquitination |
| BP | IDA | GO:0030513 | positive regulation of BMP signaling pathway |
| BP | IMP | GO:0042147 | retrograde transport, endosome to Golgi |
| BP | IMP | GO:0070534 | protein K63-linked ubiquitination |
Gene expression in normal tissue: UBE2O
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBE2O
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| humancyc | PWY-7511 | protein ubiquitylation |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD297 | Austocystin D | 4 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD116 | CD437 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UBE2O
CLASSFICATION
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