CAMKK1
Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium/calmodulin dependent protein kinase kinase 1 | MIM:611411 | Ensembl:ENSG00000004660 | HGNC:HGNC:1469 | PA26051 | 17p13.2 |
GO terms in CAMKK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | TAS | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0045860 | positive regulation of protein kinase activity |
Gene expression in normal tissue: CAMKK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAMKK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-442717 | CREB phosphorylation through the activation of CaMKK |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| biocarta | cacampathway | ca-calmodulin-dependent protein kinase activation |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | pgc1apathway | regulation of pgc-1a |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD394 | BX-795 | 5 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD405 | PIK-75 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAMKK1
CLASSFICATION
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