CAMKK1

Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecalcium/calmodulin dependent protein kinase kinase 1
OMIM IDMIM:611411
Ensembl IDEnsembl:ENSG00000004660
HGNC IDHGNC:HGNC:1469
PHARMGKB IDPA26051
Map Location17p13.2

GO terms in CAMKK1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004683 calmodulin-dependent protein kinase activity
MF TAS GO:0004683 calmodulin-dependent protein kinase activity
MF IPI GO:0005515 protein binding
MF IBA GO:0005516 calmodulin binding
MF IEA GO:0005524 ATP binding
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Gene expression in normal tissue: CAMKK1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 26LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 9

Gene-drug pathway distribution

undefined15IGFR signaling1DNA replication1Drug metabolism - cytochrome P4501

Pathways in CAMKK1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
reactome R-HSA-112315 Transmission across Chemical Synapses
reactome R-HSA-112316 Neuronal System
reactome R-HSA-438064 Post NMDA receptor activation events
reactome R-HSA-442717 CREB phosphorylation through the activation of CaMKK
reactome R-HSA-442755 Activation of NMDA receptor and postsynaptic events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD188 Piperlongumine 3
iGMDRD286 Nsc 632839 3
iGMDRD872 BRD7137 3
iGMDRD60 Quinoclamine 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMKK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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