EPHA5


Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor A5MIM:600004Ensembl:ENSG00000145242HGNC:HGNC:3389PA278214q13.1-q13.2

GO terms in EPHA5


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0007275multicellular organism development
BPISSGO:0007411axon guidance
BPIBAGO:0009968negative regulation of signal transduction
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0019933cAMP-mediated signaling
BPISSGO:0021766hippocampus development
BPIBAGO:0030154cell differentiation
BPISSGO:0032793positive regulation of CREB transcription factor activity
BPISSGO:0032956regulation of actin cytoskeleton organization
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPISSGO:0043087regulation of GTPase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPISSGO:0048013ephrin receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPIEPGO:0048666neuron development
BPISSGO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
CCIBAGO:0005737cytoplasm
CCIDAGO:0005791rough endoplasmic reticulum
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIDAGO:0009897external side of plasma membrane
CCIEAGO:0030424axon
CCIDAGO:0030425dendrite
CCIBAGO:0043005neuron projection
CCIDAGO:0043025neuronal cell body
CCIBAGO:0043235receptor complex
CCIDAGO:0048471perinuclear region of cytoplasm
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFISSGO:0005003ephrin receptor activity
MFISSGO:0005004GPI-linked ephrin receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFNASGO:0005005transmembrane-ephrin receptor activity
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding

Gene expression in normal tissue: EPHA5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA5


DatabasePathway IDPathway Des.
kegghsa04360Axon guidance - Homo sapiens (human)
pidepha_fwdpathwayEPHA forward signaling
pidephrinarevpathwayEphrin A reverse signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD885Compound 1101
iGMDRD318PAC-15
iGMDRD52Rotenone2
iGMDRD187BRD98763
iGMDRD491TAE-6841
iGMDRD23Gossypol4
iGMDRD64Parbendazole6
iGMDRD398Sepantronium2
iGMDRD399Selumetinib3
iGMDRD74Idarubicin3
iGMDRD887Compound 23 citrate3
iGMDRD781Sirolimus1
iGMDRD144NSC953972
iGMDRD670ML 2103
iGMDRD76Simvastatin2
iGMDRD151CHM-17
iGMDRD433Lexibulin1
iGMDRD554CHEMBL14341373
iGMDRD210AC556493
iGMDRD634SCHEMBL26080411
iGMDRD394BX-7954
iGMDRD466Chaetocin2
iGMDRD280CYTOCHALASIN B6
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD193Fqi13
iGMDRD152179324-69-75
iGMDRD446LY 21832401
iGMDRD481Dactolisib2
iGMDRD221Tamoxifen1
iGMDRD705Nakiterpiosin3
iGMDRD105Triptolide3
iGMDRD103SN-382
iGMDRD202Curcumin3
iGMDRD158NSC1415402
iGMDRD121GMX17786
iGMDRD322FK 8666
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat2
iGMDRD329Merck602
iGMDRD871BRD63682
iGMDRD286Nsc 6328392
iGMDRD414MST-3125
iGMDRD701NVP-AUY9225
iGMDRD405PIK-752
iGMDRD150RITA3
iGMDRD424Tamatinib2
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD512nutlin 35
iGMDRD607Ubistatin B2
iGMDRD84Lovastatin acid4
iGMDRD48Dexamethasone2
iGMDRD945ML2142
iGMDRD883CIL55A2
iGMDRD901ELCPK8
iGMDRD211(1S,3R)-RSL33
iGMDRD123Isoevodiamine5
iGMDRD698Neratinib5
iGMDRD57Chloropentafluorobenzene2
iGMDRD351GW843682X2
iGMDRD499PDMP3
iGMDRD237ABT-7512

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA5

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