SEARCH

HOME / SEARCH / EPHA5

EPHA5

Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
EPH receptor A5	MIM:600004	Ensembl:ENSG00000145242	HGNC:HGNC:3389	PA27821	4q13.1-q13.2

Gene Categories:

CELL SURFACE KINASE CLINICALLY ACTIONABLE EXTERNAL SIDE OF PLASMA MEMBRANE TYROSINE KINASE DRUGGABLE GENOME

GO terms in EPHA5

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0007275	multicellular organism development
BP	ISS	GO:0007411	axon guidance
BP	IBA	GO:0009968	negative regulation of signal transduction
BP	IEA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	ISS	GO:0019933	cAMP-mediated signaling
BP	ISS	GO:0021766	hippocampus development
BP	IBA	GO:0030154	cell differentiation
BP	ISS	GO:0032793	positive regulation of CREB transcription factor activity
BP	ISS	GO:0032956	regulation of actin cytoskeleton organization
BP	IBA	GO:0033674	positive regulation of kinase activity
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	ISS	GO:0043087	regulation of GTPase activity
BP	IBA	GO:0043410	positive regulation of MAPK cascade
BP	ISS	GO:0048013	ephrin receptor signaling pathway
BP	TAS	GO:0048013	ephrin receptor signaling pathway
BP	IEP	GO:0048666	neuron development
BP	ISS	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
BP	IBA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005791	rough endoplasmic reticulum
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0009897	external side of plasma membrane
CC	IEA	GO:0030424	axon
CC	IDA	GO:0030425	dendrite
CC	IBA	GO:0043005	neuron projection
CC	IDA	GO:0043025	neuronal cell body
CC	IBA	GO:0043235	receptor complex
CC	IDA	GO:0048471	perinuclear region of cytoplasm
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	ISS	GO:0005003	ephrin receptor activity
MF	ISS	GO:0005004	GPI-linked ephrin receptor activity
MF	IBA	GO:0005005	transmembrane-ephrin receptor activity
MF	NAS	GO:0005005	transmembrane-ephrin receptor activity
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0031434	mitogen-activated protein kinase kinase binding

Gene expression in normal tissue: EPHA5

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA5

Database	Pathway ID	Pathway Des.
kegg	hsa04360	Axon guidance - Homo sapiens (human)
pid	epha_fwdpathway	EPHA forward signaling
pid	ephrinarevpathway	Ephrin A reverse signaling
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-422475	Axon guidance

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD885	Compound 110	1
iGMDRD318	PAC-1	5
iGMDRD52	Rotenone	2
iGMDRD187	BRD9876	3
iGMDRD491	TAE-684	1
iGMDRD23	Gossypol	4
iGMDRD64	Parbendazole	6
iGMDRD398	Sepantronium	2
iGMDRD399	Selumetinib	3
iGMDRD74	Idarubicin	3
iGMDRD887	Compound 23 citrate	3
iGMDRD781	Sirolimus	1
iGMDRD144	NSC95397	2
iGMDRD670	ML 210	3
iGMDRD76	Simvastatin	2
iGMDRD151	CHM-1	7
iGMDRD433	Lexibulin	1
iGMDRD554	CHEMBL1434137	3
iGMDRD210	AC55649	3
iGMDRD634	SCHEMBL2608041	1
iGMDRD394	BX-795	4
iGMDRD466	Chaetocin	2
iGMDRD280	CYTOCHALASIN B	6
iGMDRD316	N9-Isopropyl-olomoucine	3
iGMDRD193	Fqi1	3
iGMDRD152	179324-69-7	5
iGMDRD446	LY 2183240	1
iGMDRD481	Dactolisib	2
iGMDRD221	Tamoxifen	1
iGMDRD705	Nakiterpiosin	3
iGMDRD105	Triptolide	3
iGMDRD103	SN-38	2
iGMDRD202	Curcumin	3
iGMDRD158	NSC141540	2
iGMDRD121	GMX1778	6
iGMDRD322	FK 866	6
iGMDRD886	Compound 1541A	2
iGMDRD505	Pevonedistat	2
iGMDRD329	Merck60	2
iGMDRD871	BRD6368	2
iGMDRD286	Nsc 632839	2
iGMDRD414	MST-312	5
iGMDRD701	NVP-AUY922	5
iGMDRD405	PIK-75	2
iGMDRD150	RITA	3
iGMDRD424	Tamatinib	2
iGMDRD345	Compound 10b [PMID: 11504634]	2
iGMDRD512	nutlin 3	5
iGMDRD607	Ubistatin B	2
iGMDRD84	Lovastatin acid	4
iGMDRD48	Dexamethasone	2
iGMDRD945	ML214	2
iGMDRD883	CIL55A	2
iGMDRD901	ELCPK	8
iGMDRD211	(1S,3R)-RSL3	3
iGMDRD123	Isoevodiamine	5
iGMDRD698	Neratinib	5
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD351	GW843682X	2
iGMDRD499	PDMP	3
iGMDRD237	ABT-751	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA5

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.