GRB7
Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601522 Ensembl IDEnsembl:ENSG00000141738 HGNC IDHGNC:HGNC:4567 PHARMGKB IDPA28963 Map Location17q12 | |||||
GO terms in GRB7
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003723 | RNA binding |
| MF | IEA | GO:0005070 | SH3/SH2 adaptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0035091 | phosphatidylinositol binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: GRB7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRB7
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1306955 | GRB7 events in ERBB2 signaling |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRB7
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.