GRB7
Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| growth factor receptor bound protein 7 | MIM:601522 | Ensembl:ENSG00000141738 | HGNC:HGNC:4567 | PA28963 | 17q12 |
GO terms in GRB7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003723 | RNA binding |
| MF | IEA | GO:0005070 | SH3/SH2 adaptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0035091 | phosphatidylinositol binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0010494 | cytoplasmic stress granule |
| CC | IEA | GO:0042995 | cell projection |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0009967 | positive regulation of signal transduction |
| BP | ISS | GO:0017148 | negative regulation of translation |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | ISS | GO:0034063 | stress granule assembly |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | TAS | GO:0050900 | leukocyte migration |
Gene expression in normal tissue: GRB7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRB7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1306955 | GRB7 events in ERBB2 signaling |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_KitReceptor | KitReceptor |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 11 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD366 | PI-103 | 13 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD506 | Fedratinib | 9 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD375 | GW-405833 | 6 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD49 | Mitomycin | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRB7
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