AATK
Summary: The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| apoptosis associated tyrosine kinase | MIM:605276 | Ensembl:ENSG00000181409 | HGNC:HGNC:21 | PA24370 | 17q25.3 |
GO terms in AATK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ND | GO:0005575 | cellular_component |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | ND | GO:0008150 | biological_process |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: AATK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AATK
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD116 | CD437 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD74 | Idarubicin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AATK
CLASSFICATION
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