ACVR1C
Summary: ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| activin A receptor type 1C | MIM:608981 | Ensembl:ENSG00000123612 | HGNC:HGNC:18123 | PA134908988 | 2q24.1 |
GO terms in ACVR1C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002021 | response to dietary excess |
| BP | IC | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IBA | GO:0007389 | pattern specification process |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0019915 | lipid storage |
| BP | IDA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030262 | apoptotic nuclear changes |
| BP | IEA | GO:0032868 | response to insulin |
| BP | IBA | GO:0032924 | activin receptor signaling pathway |
| BP | IMP | GO:0038092 | nodal signaling pathway |
| BP | IMP | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0046676 | negative regulation of insulin secretion |
| BP | IDA | GO:1901164 | negative regulation of trophoblast cell migration |
| BP | IMP | GO:1901383 | negative regulation of chorionic trophoblast cell proliferation |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IBA | GO:0048179 | activin receptor complex |
| CC | IDA | GO:0048179 | activin receptor complex |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0005024 | transforming growth factor beta-activated receptor activity |
| MF | IBA | GO:0005025 | transforming growth factor beta receptor activity, type I |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016361 | activin receptor activity, type I |
| MF | IBA | GO:0019838 | growth factor binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | IMP | GO:0038100 | nodal binding |
| MF | IBA | GO:0046332 | SMAD binding |
| MF | IC | GO:0046872 | metal ion binding |
| MF | IBA | GO:0048185 | activin binding |
Gene expression in normal tissue: ACVR1C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACVR1C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1433617 | Regulation of signaling by NODAL |
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD499 | PDMP | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACVR1C
CLASSFICATION
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