DAXX
Summary: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| death domain associated protein | MIM:603186 | Ensembl:ENSG00000204209 | HGNC:HGNC:2681 | PA27148 | 6p21.32 |
GO terms in DAXX
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IGI | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0006334 | nucleosome assembly |
| BP | IDA | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007257 | activation of JUN kinase activity |
| BP | TAS | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0030521 | androgen receptor signaling pathway |
| BP | IDA | GO:0031396 | regulation of protein ubiquitination |
| BP | IDA | GO:0034605 | cellular response to heat |
| BP | IDA | GO:0034620 | cellular response to unfolded protein |
| BP | IGI | GO:0045860 | positive regulation of protein kinase activity |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0071276 | cellular response to cadmium ion |
| BP | IDA | GO:0071280 | cellular response to copper ion |
| BP | IDA | GO:0072738 | cellular response to diamide |
| BP | IGI | GO:1901216 | positive regulation of neuron death |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
| BP | IDA | GO:1903936 | cellular response to sodium arsenite |
| CC | IDA | GO:0000775 | chromosome, centromeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0016605 | PML body |
| CC | TAS | GO:0016605 | PML body |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IMP | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IGI | GO:0030295 | protein kinase activator activity |
| MF | TAS | GO:0031072 | heat shock protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0032183 | SUMO binding |
| MF | IDA | GO:0042393 | histone binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | IPI | GO:0050681 | androgen receptor binding |
Gene expression in normal tissue: DAXX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DAXX
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | pmlpathway | regulation of transcriptional activity by pml |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | p53regulationpathway | p53 pathway |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 4 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD698 | Neratinib | 4 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD67 | PENFLURIDOL | 6 |
| iGMDRD577 | BIX01294 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DAXX
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