DAXX


Summary: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
death domain associated proteinMIM:603186Ensembl:ENSG00000204209HGNC:HGNC:2681PA271486p21.32

GO terms in DAXX


Term TypeEvidence TypeGO Term IDGO Des.
BPIGIGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0006334nucleosome assembly
BPIDAGO:0006338chromatin remodeling
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006915apoptotic process
BPTASGO:0007257activation of JUN kinase activity
BPTASGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIEAGO:0016032viral process
BPIDAGO:0030521androgen receptor signaling pathway
BPIDAGO:0031396regulation of protein ubiquitination
BPIDAGO:0034605cellular response to heat
BPIDAGO:0034620cellular response to unfolded protein
BPIGIGO:0045860positive regulation of protein kinase activity
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0071276cellular response to cadmium ion
BPIDAGO:0071280cellular response to copper ion
BPIDAGO:0072738cellular response to diamide
BPIGIGO:1901216positive regulation of neuron death
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
BPIDAGO:1903936cellular response to sodium arsenite
CCIDAGO:0000775chromosome, centromeric region
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIEAGO:0005730nucleolus
CCTASGO:0005737cytoplasm
CCISSGO:0005829cytosol
CCIDAGO:0016604nuclear body
CCIDAGO:0016605PML body
CCTASGO:0016605PML body
MFIPIGO:0002039p53 binding
MFIDAGO:0003713transcription coactivator activity
MFIDAGO:0003714transcription corepressor activity
MFIMPGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019901protein kinase binding
MFIGIGO:0030295protein kinase activator activity
MFTASGO:0031072heat shock protein binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0032183SUMO binding
MFIDAGO:0042393histone binding
MFIDAGO:0046982protein heterodimerization activity
MFIPIGO:0047485protein N-terminus binding
MFIPIGO:0050681androgen receptor binding

Gene expression in normal tissue: DAXX

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DAXX


DatabasePathway IDPathway Des.
biocartafaspathwayfas signaling pathway (cd95)
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartahsp27pathwaystress induction of hsp regulation
biocartakeratinocytepathwaykeratinocyte differentiation
biocartapmlpathwayregulation of transcriptional activity by pml
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP400p38 MAPK Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidp53regulationpathwayp53 pathway
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_IL6IL6
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD150RITA4
iGMDRD427ABT7371
iGMDRD405PIK-751
iGMDRD781Sirolimus3
iGMDRD126Tipifarnib4
iGMDRD679Bistramide A3
iGMDRD634SCHEMBL26080412
iGMDRD698Neratinib4
iGMDRD152179324-69-71
iGMDRD6AM-5803
iGMDRD221Tamoxifen3
iGMDRD434BMS-5369244
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD870BRD636101
iGMDRD147Prima-13
iGMDRD23Gossypol5
iGMDRD871BRD63682
iGMDRD286Nsc 6328392
iGMDRD67PENFLURIDOL6
iGMDRD577BIX012942

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DAXX

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