PRKD1
Summary: The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase D1 | MIM:605435 | Ensembl:ENSG00000184304 | HGNC:HGNC:9407 | PA33771 | 14q12 |
GO terms in PRKD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004697 | protein kinase C activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0000421 | autophagosome membrane |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IGI | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | IMP | GO:0007265 | Ras protein signal transduction |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IMP | GO:0010508 | positive regulation of autophagy |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | ISS | GO:0010837 | regulation of keratinocyte proliferation |
| BP | IMP | GO:0010976 | positive regulation of neuron projection development |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IMP | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IGI | GO:0032793 | positive regulation of CREB transcription factor activity |
| BP | IGI | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IMP | GO:0034198 | cellular response to amino acid starvation |
| BP | IDA | GO:0034599 | cellular response to oxidative stress |
| BP | IMP | GO:0035556 | intracellular signal transduction |
| BP | IGI | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IGI | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IGI | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IC | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IEA | GO:0045087 | innate immune response |
| BP | ISS | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IGI | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | TAS | GO:0045806 | negative regulation of endocytosis |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | ISS | GO:0048193 | Golgi vesicle transport |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0060548 | negative regulation of cell death |
| BP | IMP | GO:0071447 | cellular response to hydroperoxide |
| BP | IBA | GO:0089700 | protein kinase D signaling |
| BP | IGI | GO:0089700 | protein kinase D signaling |
| BP | IGI | GO:1901727 | positive regulation of histone deacetylase activity |
| BP | IMP | GO:2001028 | positive regulation of endothelial cell chemotaxis |
| BP | TAS | GO:2001044 | regulation of integrin-mediated signaling pathway |
Gene expression in normal tissue: PRKD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKD1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| pid | igf1_pathway | IGF1 pathway |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD874 | BRD8958 | 3 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD260 | FQI-2 | 6 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD207 | Capsaicin | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD394 | BX-795 | 5 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD150 | RITA | 1 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD630 | ML203 | 2 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD193 | Fqi1 | 7 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD579 | PF750 | 6 |
| iGMDRD229 | B02 | 1 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD267 | Oligomycin A | 7 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD192 | CIL56 | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD435 | BI-2536 | 2 |
| iGMDRD901 | ELCPK | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD701 | NVP-AUY922 | 6 |
| iGMDRD424 | Tamatinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKD1
CLASSFICATION
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