PRKD1


Summary: The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase D1MIM:605435Ensembl:ENSG00000184304HGNC:HGNC:9407PA3377114q12

GO terms in PRKD1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004674protein serine/threonine kinase activity
MFIMPGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004697protein kinase C activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0016301kinase activity
MFIPIGO:0042802identical protein binding
MFIEAGO:0046872metal ion binding
CCIDAGO:0000421autophagosome membrane
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005802trans-Golgi network
CCIDAGO:0005829cytosol
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
BPIEAGO:0001525angiogenesis
BPIGIGO:0001938positive regulation of endothelial cell proliferation
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0006915apoptotic process
BPIEAGO:0006954inflammatory response
BPIMPGO:0007030Golgi organization
BPTASGO:0007165signal transduction
BPTASGO:0007229integrin-mediated signaling pathway
BPIMPGO:0007265Ras protein signal transduction
BPTASGO:0008283cell proliferation
BPIMPGO:0010508positive regulation of autophagy
BPIMPGO:0010595positive regulation of endothelial cell migration
BPISSGO:0010837regulation of keratinocyte proliferation
BPIMPGO:0010976positive regulation of neuron projection development
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPIMPGO:0018107peptidyl-threonine phosphorylation
BPTASGO:0030148sphingolipid biosynthetic process
BPIMPGO:0031647regulation of protein stability
BPIGIGO:0032793positive regulation of CREB transcription factor activity
BPIGIGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIMPGO:0034198cellular response to amino acid starvation
BPIDAGO:0034599cellular response to oxidative stress
BPIMPGO:0035556intracellular signal transduction
BPIGIGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIGIGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
BPIMPGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
BPIMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIGIGO:0043536positive regulation of blood vessel endothelial cell migration
BPIMPGO:0043536positive regulation of blood vessel endothelial cell migration
BPICGO:0043552positive regulation of phosphatidylinositol 3-kinase activity
BPIEAGO:0045087innate immune response
BPISSGO:0045669positive regulation of osteoblast differentiation
BPIGIGO:0045766positive regulation of angiogenesis
BPIMPGO:0045766positive regulation of angiogenesis
BPTASGO:0045806negative regulation of endocytosis
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046777protein autophosphorylation
BPTASGO:0046777protein autophosphorylation
BPIMPGO:0048010vascular endothelial growth factor receptor signaling pathway
BPISSGO:0048193Golgi vesicle transport
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0060548negative regulation of cell death
BPIMPGO:0071447cellular response to hydroperoxide
BPIBAGO:0089700protein kinase D signaling
BPIGIGO:0089700protein kinase D signaling
BPIGIGO:1901727positive regulation of histone deacetylase activity
BPIMPGO:2001028positive regulation of endothelial cell chemotaxis
BPTASGO:2001044regulation of integrin-mediated signaling pathway

Gene expression in normal tissue: PRKD1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKD1


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1660661Sphingolipid de novo biosynthesis
reactomeR-HSA-428157Sphingolipid metabolism
reactomeR-HSA-556833Metabolism of lipids
netpathPathway_BCRBCR
netpathPathway_EGFR1EGFR1
netpathPathway_TCRTCR
pidigf1_pathwayIGF1 pathway
pidlysophospholipid_pathwayLPA receptor mediated events
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP536Calcium Regulation in the Cardiac Cell

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD506Fedratinib1
iGMDRD399Selumetinib2
iGMDRD356PNU-746541
iGMDRD23Gossypol2
iGMDRD874BRD89583
iGMDRD64Parbendazole4
iGMDRD260FQI-26
iGMDRD187BRD98764
iGMDRD52Rotenone4
iGMDRD226ML0062
iGMDRD207Capsaicin3
iGMDRD61Kinetin riboside2
iGMDRD394BX-7955
iGMDRD679Bistramide A2
iGMDRD466Chaetocin2
iGMDRD420Leucascandrolide A4
iGMDRD889Compound 7d-cis2
iGMDRD151CHM-16
iGMDRD126Tipifarnib1
iGMDRD781Sirolimus1
iGMDRD670ML 2102
iGMDRD546BMS-7548071
iGMDRD366PI-1031
iGMDRD367Ro 28-16752
iGMDRD871BRD63681
iGMDRD322FK 8665
iGMDRD147Prima-11
iGMDRD158NSC1415401
iGMDRD121GMX17784
iGMDRD103SN-383
iGMDRD213SMR0000686503
iGMDRD77Itraconazole6
iGMDRD705Nakiterpiosin6
iGMDRD221Tamoxifen2
iGMDRD289Parthenolide1
iGMDRD237ABT-7512
iGMDRD341Triacsin c1
iGMDRD154NSC237663
iGMDRD945ML2141
iGMDRD123Isoevodiamine3
iGMDRD523Cyanoquinoline, 114
iGMDRD150RITA1
iGMDRD560MK-22063
iGMDRD398Sepantronium1
iGMDRD100Zebularine1
iGMDRD630ML2032
iGMDRD60Quinoclamine4
iGMDRD138PX 123
iGMDRD870BRD636103
iGMDRD441TW 371
iGMDRD193Fqi17
iGMDRD446LY 21832404
iGMDRD634SCHEMBL26080411
iGMDRD297Austocystin D2
iGMDRD579PF7506
iGMDRD229B021
iGMDRD494Neopeltolide4
iGMDRD872BRD71374
iGMDRD246NPC261
iGMDRD300Tozasertib1
iGMDRD505Pevonedistat6
iGMDRD886Compound 1541A1
iGMDRD267Oligomycin A7
iGMDRD481Dactolisib1
iGMDRD192CIL562
iGMDRD6AM-5802
iGMDRD351GW843682X3
iGMDRD435BI-25362
iGMDRD901ELCPK4
iGMDRD211(1S,3R)-RSL32
iGMDRD512nutlin 31
iGMDRD84Lovastatin acid3
iGMDRD701NVP-AUY9226
iGMDRD424Tamatinib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKD1

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