ACACA

Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameacetyl-CoA carboxylase alpha
OMIM IDMIM:200350
Ensembl IDEnsembl:ENSG00000278540
HGNC IDHGNC:HGNC:84
PHARMGKB IDPA24421
Map Location17q12

Gene Categories:

DRUGGABLE GENOME

GO terms in ACACA


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001894 tissue homeostasis
BP ISS GO:0006084 acetyl-CoA metabolic process
BP ISS GO:0006633 fatty acid biosynthetic process
BP TAS GO:0006853 carnitine shuttle
BP IEA GO:0019538 protein metabolic process
BP TAS GO:0031325 positive regulation of cellular metabolic process
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Gene expression in normal tissue: ACACA

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 81undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 6undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 6BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 20LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 44BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 13OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 2

Gene-drug pathway distribution

undefined50Apoptosis regulation3DNA replication2Ferroptosis1Cell cycle1p53 pathway1Other, kinases1IGFR signaling1JNK and p38 signaling1Drug metabolism - cytochrome P4501

Pathways in ACACA


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-163685 Integration of energy metabolism
reactome R-HSA-163765 ChREBP activates metabolic gene expression
reactome R-HSA-1643685 Disease
reactome R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactome R-HSA-196780 Biotin transport and metabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD945 ML214 3
iGMDRD523 Cyanoquinoline, 11 4
iGMDRD405 PIK-75 5
iGMDRD150 RITA 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACACA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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