ACACA
Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| acetyl-CoA carboxylase alpha | MIM:200350 | Ensembl:ENSG00000278540 | HGNC:HGNC:84 | PA24421 | 17q12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ACACA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001894 | tissue homeostasis |
| BP | ISS | GO:0006084 | acetyl-CoA metabolic process |
| BP | ISS | GO:0006633 | fatty acid biosynthetic process |
| BP | TAS | GO:0006853 | carnitine shuttle |
| BP | IEA | GO:0019538 | protein metabolic process |
| BP | TAS | GO:0031325 | positive regulation of cellular metabolic process |
| BP | TAS | GO:0045540 | regulation of cholesterol biosynthetic process |
| BP | TAS | GO:0046949 | fatty-acyl-CoA biosynthetic process |
| BP | ISS | GO:0051289 | protein homotetramerization |
| BP | IEA | GO:0055088 | lipid homeostasis |
| BP | IEA | GO:0071380 | cellular response to prostaglandin E stimulus |
| BP | IEA | GO:2001295 | malonyl-CoA biosynthetic process |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| MF | ISS | GO:0003989 | acetyl-CoA carboxylase activity |
| MF | TAS | GO:0003989 | acetyl-CoA carboxylase activity |
| MF | IEA | GO:0004075 | biotin carboxylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ACACA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACACA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163765 | ChREBP activates metabolic gene expression |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| reactome | R-HSA-196780 | Biotin transport and metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-200425 | Import of palmitoyl-CoA into the mitochondrial matrix |
| reactome | R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) |
| reactome | R-HSA-3296482 | Defects in vitamin and cofactor metabolism |
| reactome | R-HSA-3323169 | Defects in biotin (Btn) metabolism |
| reactome | R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5668914 | Diseases of metabolism |
| reactome | R-HSA-75105 | Fatty acyl-CoA biosynthesis |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| biocarta | leptinpathway | reversal of insulin resistance by leptin |
| humancyc | PWY-5966-1 | fatty acid biosynthesis initiation |
| humancyc | PWY0-1264 | biotin-carboxyl carrier protein assembly |
| kegg | hsa00061 | Fatty acid biosynthesis - Homo sapiens (human) |
| kegg | hsa00620 | Pyruvate metabolism - Homo sapiens (human) |
| kegg | hsa00640 | Propanoate metabolism - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| netpath | Pathway_Ghrelin | Ghrelin |
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| smpdb | SMP00016 | Propanoate Metabolism |
| smpdb | SMP00060 | Pyruvate Metabolism |
| smpdb | SMP00196 | Leigh Syndrome |
| smpdb | SMP00198 | Malonic Aciduria |
| smpdb | SMP00201 | Methylmalonic Aciduria Due to Cobalamin-Related Disorders |
| smpdb | SMP00212 | Pyruvate Dehydrogenase Complex Deficiency |
| smpdb | SMP00334 | Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) |
| smpdb | SMP00456 | Fatty Acid Biosynthesis |
| smpdb | SMP00502 | Malonyl-coa decarboxylase deficiency |
| smpdb | SMP00558 | Primary hyperoxaluria II, PH2 |
| smpdb | SMP00559 | Pyruvate kinase deficiency |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP357 | Fatty Acid Biosynthesis |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3934 | Leptin and adiponectin |
| wikipathways | WP3965 | Lipid Metabolism Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4206 | Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD405 | PIK-75 | 5 |
| iGMDRD150 | RITA | 4 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD396 | AS601245 | 1 |
| iGMDRD221 | Tamoxifen | 6 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD874 | BRD8958 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD307 | Manumycin A | 5 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD138 | PX 12 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACACA
CLASSFICATION
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