ACACA


Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
acetyl-CoA carboxylase alphaMIM:200350Ensembl:ENSG00000278540HGNC:HGNC:84PA2442117q12

Gene Categories:

DRUGGABLE GENOME

GO terms in ACACA


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001894tissue homeostasis
BPISSGO:0006084acetyl-CoA metabolic process
BPISSGO:0006633fatty acid biosynthetic process
BPTASGO:0006853carnitine shuttle
BPIEAGO:0019538protein metabolic process
BPTASGO:0031325positive regulation of cellular metabolic process
BPTASGO:0045540regulation of cholesterol biosynthetic process
BPTASGO:0046949fatty-acyl-CoA biosynthetic process
BPISSGO:0051289protein homotetramerization
BPIEAGO:0055088lipid homeostasis
BPIEAGO:0071380cellular response to prostaglandin E stimulus
BPIEAGO:2001295malonyl-CoA biosynthetic process
CCIDAGO:0001650fibrillar center
CCIDAGO:0005829cytosol
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0015629actin cytoskeleton
MFISSGO:0003989acetyl-CoA carboxylase activity
MFTASGO:0003989acetyl-CoA carboxylase activity
MFIEAGO:0004075biotin carboxylase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: ACACA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACACA


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163765ChREBP activates metabolic gene expression
reactomeR-HSA-1643685Disease
reactomeR-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactomeR-HSA-196780Biotin transport and metabolism
reactomeR-HSA-196849Metabolism of water-soluble vitamins and cofactors
reactomeR-HSA-196854Metabolism of vitamins and cofactors
reactomeR-HSA-200425Import of palmitoyl-CoA into the mitochondrial matrix
reactomeR-HSA-2426168Activation of gene expression by SREBF (SREBP)
reactomeR-HSA-3296482Defects in vitamin and cofactor metabolism
reactomeR-HSA-3323169Defects in biotin (Btn) metabolism
reactomeR-HSA-3371599Defective HLCS causes multiple carboxylase deficiency
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5668914Diseases of metabolism
reactomeR-HSA-75105Fatty acyl-CoA biosynthesis
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-8978868Fatty acid metabolism
biocartaleptinpathwayreversal of insulin resistance by leptin
humancycPWY-5966-1fatty acid biosynthesis initiation
humancycPWY0-1264biotin-carboxyl carrier protein assembly
kegghsa00061Fatty acid biosynthesis - Homo sapiens (human)
kegghsa00620Pyruvate metabolism - Homo sapiens (human)
kegghsa00640Propanoate metabolism - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
netpathPathway_GhrelinGhrelin
pharmgkbPA165948566Metformin Pathway, Pharmacodynamic
smpdbSMP00016Propanoate Metabolism
smpdbSMP00060Pyruvate Metabolism
smpdbSMP00196Leigh Syndrome
smpdbSMP00198Malonic Aciduria
smpdbSMP00201Methylmalonic Aciduria Due to Cobalamin-Related Disorders
smpdbSMP00212Pyruvate Dehydrogenase Complex Deficiency
smpdbSMP00334Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
smpdbSMP00456Fatty Acid Biosynthesis
smpdbSMP00502Malonyl-coa decarboxylase deficiency
smpdbSMP00558Primary hyperoxaluria II, PH2
smpdbSMP00559Pyruvate kinase deficiency
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP357Fatty Acid Biosynthesis
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3934Leptin and adiponectin
wikipathwaysWP3965Lipid Metabolism Pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4206Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD945ML2143
iGMDRD523Cyanoquinoline, 114
iGMDRD405PIK-755
iGMDRD150RITA4
iGMDRD552AZD-17752
iGMDRD367Ro 28-16752
iGMDRD871BRD63685
iGMDRD77Itraconazole3
iGMDRD396AS6012451
iGMDRD221Tamoxifen6
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide3
iGMDRD103SN-381
iGMDRD202Curcumin5
iGMDRD121GMX17782
iGMDRD158NSC1415402
iGMDRD466Chaetocin2
iGMDRD670ML 2101
iGMDRD546BMS-7548072
iGMDRD427ABT7372
iGMDRD889Compound 7d-cis2
iGMDRD151CHM-11
iGMDRD874BRD89583
iGMDRD23Gossypol1
iGMDRD888Compound 441
iGMDRD506Fedratinib1
iGMDRD188Piperlongumine5
iGMDRD260FQI-21
iGMDRD474Avrainvillamide3
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD211(1S,3R)-RSL31
iGMDRD177Teniposide4
iGMDRD351GW843682X3
iGMDRD116CD4375
iGMDRD424Tamatinib2
iGMDRD512nutlin 33
iGMDRD148Pifithrin-mu3
iGMDRD307Manumycin A5
iGMDRD82Quiflapon1
iGMDRD505Pevonedistat4
iGMDRD246NPC262
iGMDRD414MST-3123
iGMDRD872BRD71374
iGMDRD415LE-1351
iGMDRD267Oligomycin A4
iGMDRD6AM-5801
iGMDRD271Brefeldin A1
iGMDRD634SCHEMBL26080413
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B3
iGMDRD446LY 21832402
iGMDRD201SKI II3
iGMDRD772BRD47701
iGMDRD579PF7502
iGMDRD268Cerulenin2
iGMDRD451Serdemetan3
iGMDRD60Quinoclamine6
iGMDRD577BIX012943
iGMDRD562Navitoclax5
iGMDRD318PAC-11
iGMDRD885Compound 1101
iGMDRD441TW 372
iGMDRD782DC-45-A23
iGMDRD255SB2250022
iGMDRD138PX 123

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACACA

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