IL1R1

Summary: This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinterleukin 1 receptor type 1
OMIM IDMIM:147810
Ensembl IDEnsembl:ENSG00000115594
HGNC IDHGNC:HGNC:5993
PHARMGKB IDPA29809
Map Location2q11.2-q12.1

GO terms in IL1R1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0002020 protease binding
MF TAS GO:0004888 transmembrane signaling receptor activity
MF IDA GO:0004908 interleukin-1 receptor activity
MF IEA GO:0004909 interleukin-1, type I, activating receptor activity
MF IPI GO:0005161 platelet-derived growth factor receptor binding
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: IL1R1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 78undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 6LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 33BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined33Protein stability and degradation2Apoptosis regulation2PI3K/MTOR signaling1Drug metabolism - cytochrome P4501Stilbenoid, diarylheptanoid and gingerol biosynthesis1Biosynthesis of secondary metabolites1DNA replication1

Pathways in IL1R1


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Database
Pathway ID
Pathway Des.
wikipathways WP1455 Serotonin Transporter Activity
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP195 IL-1 signaling pathway
wikipathways WP2431 Spinal Cord Injury
wikipathways WP2637 Structural Pathway of Interleukin 1 (IL-1)
wikipathways WP2865 IL1 and megakaryocytes in obesity
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD801 2,4-dideoxy-DC-45-A2 1
iGMDRD318 PAC-1 2
iGMDRD52 Rotenone 3
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL1R1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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