IL1R1


Summary: This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interleukin 1 receptor type 1MIM:147810Ensembl:ENSG00000115594HGNC:HGNC:5993PA298092q11.2-q12.1

GO terms in IL1R1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0002020protease binding
MFTASGO:0004888transmembrane signaling receptor activity
MFIDAGO:0004908interleukin-1 receptor activity
MFIEAGO:0004909interleukin-1, type I, activating receptor activity
MFIPIGO:0005161platelet-derived growth factor receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0019966interleukin-1 binding
BPTASGO:0006955immune response
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIDAGO:0032729positive regulation of interferon-gamma production
BPIEAGO:0050727regulation of inflammatory response
BPIDAGO:0070498interleukin-1-mediated signaling pathway
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIDAGO:0070555response to interleukin-1
BPIEAGO:2000391positive regulation of neutrophil extravasation
BPIDAGO:2000556positive regulation of T-helper 1 cell cytokine production
BPIEAGO:2000661positive regulation of interleukin-1-mediated signaling pathway
CCIEAGO:0005576extracellular region
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIDAGO:0016020membrane

Gene expression in normal tissue: IL1R1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL1R1


DatabasePathway IDPathway Des.
wikipathwaysWP1455Serotonin Transporter Activity
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2865IL1 and megakaryocytes in obesity
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP516Hypertrophy Model
wikipathwaysWP727Monoamine Transport
netpathPathway_IL1IL1
pidil12_2pathwayIL12-mediated signaling events
pidil1pathwayIL1-mediated signaling events
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
biocartail1rpathwaysignal transduction through il1r
biocartanfkbpathwaynf-kb signaling pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-9020702Interleukin-1 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD8012,4-dideoxy-DC-45-A21
iGMDRD318PAC-12
iGMDRD52Rotenone3
iGMDRD30917AAG1
iGMDRD188Piperlongumine3
iGMDRD577BIX012947
iGMDRD888Compound 444
iGMDRD780PP-302
iGMDRD562Navitoclax3
iGMDRD524ISX-93
iGMDRD554CHEMBL14341372
iGMDRD599Salermide3
iGMDRD889Compound 7d-cis2
iGMDRD1008SR-II-138A2
iGMDRD772BRD47705
iGMDRD427ABT7372
iGMDRD670ML 2103
iGMDRD494Neopeltolide3
iGMDRD446LY 21832403
iGMDRD201SKI II3
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD280CYTOCHALASIN B1
iGMDRD202Curcumin9
iGMDRD137Indisulam2
iGMDRD158NSC1415402
iGMDRD5Tyrphostin AG 14783
iGMDRD221Tamoxifen3
iGMDRD415LE-1353
iGMDRD871BRD63684
iGMDRD286Nsc 6328393
iGMDRD872BRD71372
iGMDRD246NPC263
iGMDRD82Quiflapon4
iGMDRD330BRD41323
iGMDRD307Manumycin A5
iGMDRD560MK-22061
iGMDRD150RITA2
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD314Tanespimycin1
iGMDRD499PDMP3
iGMDRD123Isoevodiamine2
iGMDRD132(-)-gallocatechin-3-O-gallate3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL1R1

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