IL1R1
Summary: This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 receptor type 1 | MIM:147810 | Ensembl:ENSG00000115594 | HGNC:HGNC:5993 | PA29809 | 2q11.2-q12.1 |
GO terms in IL1R1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0002020 | protease binding |
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IDA | GO:0004908 | interleukin-1 receptor activity |
| MF | IEA | GO:0004909 | interleukin-1, type I, activating receptor activity |
| MF | IPI | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019966 | interleukin-1 binding |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IDA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | IEA | GO:0050727 | regulation of inflammatory response |
| BP | IDA | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IDA | GO:0070555 | response to interleukin-1 |
| BP | IEA | GO:2000391 | positive regulation of neutrophil extravasation |
| BP | IDA | GO:2000556 | positive regulation of T-helper 1 cell cytokine production |
| BP | IEA | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway |
| CC | IEA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0016020 | membrane |
Gene expression in normal tissue: IL1R1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL1R1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1455 | Serotonin Transporter Activity |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP516 | Hypertrophy Model |
| wikipathways | WP727 | Monoamine Transport |
| netpath | Pathway_IL1 | IL1 |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il1pathway | IL1-mediated signaling events |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD202 | Curcumin | 9 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD82 | Quiflapon | 4 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD307 | Manumycin A | 5 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL1R1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.