LRP1B

Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameLDL receptor related protein 1B
OMIM IDMIM:608766
Ensembl IDEnsembl:ENSG00000168702
HGNC IDHGNC:HGNC:6693
PHARMGKB IDPA30451
Map Location2q22.1-q22.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in LRP1B


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0016021 integral component of membrane
CC IDA GO:0043235 receptor complex
BP TAS GO:0006898 receptor-mediated endocytosis
BP TAS GO:0015031 protein transport
MF IEA GO:0005509 calcium ion binding
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Gene expression in normal tissue: LRP1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined49Apoptosis regulation2RTK signaling1Drug metabolism - cytochrome P4501DNA replication1WNT signaling1Ferroptosis1Chromatin histone acetylation1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Metabolism1

Pathways in LRP1B


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD506 Fedratinib 1
iGMDRD888 Compound 44 3
iGMDRD780 PP-30 3
iGMDRD399 Selumetinib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LRP1B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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