LRP1B
Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LDL receptor related protein 1B | MIM:608766 | Ensembl:ENSG00000168702 | HGNC:HGNC:6693 | PA30451 | 2q22.1-q22.2 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in LRP1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0043235 | receptor complex |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | TAS | GO:0015031 | protein transport |
| MF | IEA | GO:0005509 | calcium ion binding |
Gene expression in normal tissue: LRP1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRP1B
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD247 | Blebbistatin | 3 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD889 | Compound 7d-cis | 7 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD670 | ML 210 | 7 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD263 | AACOCF3 | 5 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD251 | ML162 | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD248 | BRD4354 | 2 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD870 | BRD63610 | 5 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD66 | Doxorubicin | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD280 | CYTOCHALASIN B | 9 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD42 | Vorinostat | 5 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD220 | fumonisin B1 | 2 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 6 |
| iGMDRD512 | nutlin 3 | 7 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD84 | Lovastatin acid | 7 |
| iGMDRD307 | Manumycin A | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRP1B
CLASSFICATION
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