CAMK1D
Summary: This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium/calmodulin dependent protein kinase ID | MIM:607957 | Ensembl:ENSG00000183049 | HGNC:HGNC:19341 | PA134992438 | 10p13 |
GO terms in CAMK1D
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | ISS | GO:0010976 | positive regulation of neuron projection development |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IDA | GO:0032793 | positive regulation of CREB transcription factor activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0050766 | positive regulation of phagocytosis |
| BP | IMP | GO:0050773 | regulation of dendrite development |
| BP | IMP | GO:0060267 | positive regulation of respiratory burst |
| BP | IMP | GO:0071622 | regulation of granulocyte chemotaxis |
| BP | ISS | GO:0090023 | positive regulation of neutrophil chemotaxis |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: CAMK1D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAMK1D
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD67 | PENFLURIDOL | 6 |
| iGMDRD71 | Sparfosic acid | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAMK1D
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