CAMK2B
Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium/calmodulin dependent protein kinase II beta | MIM:607707 | Ensembl:ENSG00000058404 | HGNC:HGNC:1461 | PA91 | 7p13 |
GO terms in CAMK2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | IEA | GO:0033017 | sarcoplasmic reticulum membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IEA | GO:0045202 | synapse |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0010976 | positive regulation of neuron projection development |
| BP | TAS | GO:0014733 | regulation of skeletal muscle adaptation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| BP | TAS | GO:0051823 | regulation of synapse structural plasticity |
| BP | TAS | GO:0051924 | regulation of calcium ion transport |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060998 | regulation of dendritic spine development |
| BP | ISS | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| BP | ISS | GO:0090129 | positive regulation of synapse maturation |
| MF | IEA | GO:0003779 | actin binding |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: CAMK2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAMK2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3947 | Serotonin and anxiety |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| pid | ifngpathway | IFN-gamma pathway |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| pid | ras_pathway | Regulation of Ras family activation |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | cacampathway | ca-calmodulin-dependent protein kinase activation |
| biocarta | calcineurinpathway | effects of calcineurin in keratinocyte differentiation |
| biocarta | ck1pathway | regulation of ck1/cdk5 by type 1 glutamate receptors |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | hbxpathway | calcium signaling by hbx of hepatitis b virus |
| biocarta | hdacpathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | mitrpathway | signal dependent regulation of myogenesis by corepressor mitr |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
| biocarta | ndkdynaminpathway | endocytotic role of ndk phosphins and dynamin |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| biocarta | pgc1apathway | regulation of pgc-1a |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-438066 | Unblocking of NMDA receptor, glutamate binding and activation |
| reactome | R-HSA-442729 | CREB phosphorylation through the activation of CaMKII |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576892 | Phase 0 - rapid depolarisation |
| reactome | R-HSA-5578775 | Ion homeostasis |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD67 | PENFLURIDOL | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAMK2B
CLASSFICATION
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