CAMK2B


Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

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GO terms in CAMK2B


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005654 nucleoplasm
CC IBA GO:0005737 cytoplasm
CC IEA GO:0005815 microtubule organizing center
CC TAS GO:0005829 cytosol
CC TAS GO:0005886 plasma membrane
CC IEA GO:0030054 cell junction
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Gene expression in normal tissue: CAMK2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CAMK2B


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Database
Pathway ID
Pathway Des.
wikipathways WP2572 Primary Focal Segmental Glomerulosclerosis FSGS
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
wikipathways WP3947 Serotonin and anxiety
wikipathways WP4008 NO-cGMP-PKG mediated Neuroprotection
wikipathways WP428 Wnt Signaling Pathway
wikipathways WP536 Calcium Regulation in the Cardiac Cell
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD289 Parthenolide 2
iGMDRD221 Tamoxifen 2
iGMDRD6 AM-580 3
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMK2B

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Model
Level
Reference ID
Tissue
Cancer
Drug
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No matching records found

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