Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

calcium/calmodulin dependent protein kinase II betaMIM:607707Ensembl:ENSG00000058404HGNC:HGNC:1461PA917p13

GO terms in CAMK2B

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005815microtubule organizing center
CCTASGO:0005886plasma membrane
CCIEAGO:0030054cell junction
CCTASGO:0030666endocytic vesicle membrane
CCIEAGO:0033017sarcoplasmic reticulum membrane
CCIBAGO:0043005neuron projection
BPTASGO:0000165MAPK cascade
BPTASGO:0006468protein phosphorylation
BPTASGO:0007165signal transduction
BPISSGO:0010976positive regulation of neuron projection development
BPTASGO:0014733regulation of skeletal muscle adaptation
BPIDAGO:0046777protein autophosphorylation
BPTASGO:0048169regulation of long-term neuronal synaptic plasticity
BPTASGO:0051823regulation of synapse structural plasticity
BPTASGO:0051924regulation of calcium ion transport
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPTASGO:0060998regulation of dendritic spine development
BPISSGO:0061003positive regulation of dendritic spine morphogenesis
BPISSGO:0090129positive regulation of synapse maturation
MFIEAGO:0003779actin binding
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004683calmodulin-dependent protein kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0042803protein homodimerization activity

Gene expression in normal tissue: CAMK2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CAMK2B

DatabasePathway IDPathway Des.
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3947Serotonin and anxiety
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
pidifngpathwayIFN-gamma pathway
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
pidras_pathwayRegulation of Ras family activation
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04740Olfactory transduction - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartabcrpathwaybcr signaling pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacacampathwayca-calmodulin-dependent protein kinase activation
biocartacalcineurinpathwayeffects of calcineurin in keratinocyte differentiation
biocartack1pathwayregulation of ck1/cdk5 by type 1 glutamate receptors
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartagcrpathwaycorticosteroids and cardioprotection
biocartagpcrpathwaysignaling pathway from g-protein families
biocartahbxpathwaycalcium signaling by hbx of hepatitis b virus
biocartahdacpathwaycontrol of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
biocartamef2dpathwayrole of mef2d in t-cell apoptosis
biocartamitrpathwaysignal dependent regulation of myogenesis by corepressor mitr
biocartamyosinpathwaypkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
biocartandkdynaminpathwayendocytotic role of ndk phosphins and dynamin
biocartanfatpathwaynfat and hypertrophy of the heart
biocartano1pathwayactions of nitric oxide in the heart
biocartanos1pathwaynitric oxide signaling pathway
biocartapgc1apathwayregulation of pgc-1a
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartaraccpathwayion channels and their functional role in vascular endothelium
biocartastathminpathwaystathmin and breast cancer resistance to antimicrotubule agents
biocartatcrpathwayt cell receptor signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3371571HSF1-dependent transactivation
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-438066Unblocking of NMDA receptor, glutamate binding and activation
reactomeR-HSA-442729CREB phosphorylation through the activation of CaMKII
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-442982Ras activation upon Ca2+ influx through NMDA receptor
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation
reactomeR-HSA-5578775Ion homeostasis
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD441TW 372
iGMDRD286Nsc 6328395
iGMDRD886Compound 1541A2
iGMDRD523Cyanoquinoline, 113
iGMDRD85Ursolic acid1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMK2B