THRAP3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thyroid hormone receptor associated protein 3 | MIM:603809 | Ensembl:ENSG00000054118 | HGNC:HGNC:22964 | PA134893249 | 1p34.3 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in THRAP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IDA | GO:0000956 | nuclear-transcribed mRNA catabolic process |
| BP | IDA | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | IEA | GO:0008380 | RNA splicing |
| BP | IDA | GO:0030518 | intracellular steroid hormone receptor signaling pathway |
| BP | IDA | GO:0030521 | androgen receptor signaling pathway |
| BP | IMP | GO:0042753 | positive regulation of circadian rhythm |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0048026 | positive regulation of mRNA splicing, via spliceosome |
| BP | IMP | GO:0048255 | mRNA stabilization |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016592 | mediator complex |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0035145 | exon-exon junction complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | ISS | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IDA | GO:0003712 | transcription coregulator activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | NAS | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0038023 | signaling receptor activity |
| MF | NAS | GO:0042809 | vitamin D receptor binding |
| MF | IDA | GO:0046966 | thyroid hormone receptor binding |
| MF | IDA | GO:0051219 | phosphoprotein binding |
Gene expression in normal tissue: THRAP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in THRAP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD23 | Gossypol | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD441 | TW 37 | 4 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD330 | BRD4132 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in THRAP3
CLASSFICATION
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