ATP11A


Summary: The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ATPase phospholipid transporting 11AMIM:605868Ensembl:ENSG00000068650HGNC:HGNC:13552PA2510113q34

GO terms in ATP11A


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0045332phospholipid translocation
BPNASGO:0045332phospholipid translocation
BPIBAGO:0048194Golgi vesicle budding
CCHDAGO:0005765lysosomal membrane
CCIEAGO:0005769early endosome
CCIBAGO:0005783endoplasmic reticulum
CCIDAGO:0005783endoplasmic reticulum
CCIBAGO:0005802trans-Golgi network
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0035579specific granule membrane
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIBAGO:0055037recycling endosome
CCIDAGO:0055037recycling endosome
CCTASGO:0070821tertiary granule membrane
MFIEAGO:0000287magnesium ion binding
MFIBAGO:0004012phospholipid-translocating ATPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: ATP11A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP11A


DatabasePathway IDPathway Des.
wikipathwaysWP3624Lung fibrosis
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250026
iGMDRD121GMX17782
iGMDRD77Itraconazole3
iGMDRD870BRD636102
iGMDRD294Batimastat3
iGMDRD415LE-1353
iGMDRD434BMS-5369243
iGMDRD192CIL563
iGMDRD171Pemetrexed3
iGMDRD6AM-5806
iGMDRD221Tamoxifen2
iGMDRD398Sepantronium3
iGMDRD562Navitoclax3
iGMDRD329Merck602
iGMDRD67PENFLURIDOL3
iGMDRD871BRD63683
iGMDRD23Gossypol3
iGMDRD598QS-113
iGMDRD584VER 1550083
iGMDRD76Simvastatin3
iGMDRD484Pluripotin1
iGMDRD670ML 2103
iGMDRD85Ursolic acid3
iGMDRD341Triacsin c3
iGMDRD446LY 21832404
iGMDRD297Austocystin D3
iGMDRD211(1S,3R)-RSL33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP11A

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