ATP11A
Summary: The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATPase phospholipid transporting 11A | MIM:605868 | Ensembl:ENSG00000068650 | HGNC:HGNC:13552 | PA25101 | 13q34 |
GO terms in ATP11A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0045332 | phospholipid translocation |
| BP | NAS | GO:0045332 | phospholipid translocation |
| BP | IBA | GO:0048194 | Golgi vesicle budding |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IEA | GO:0005769 | early endosome |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005802 | trans-Golgi network |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IBA | GO:0055037 | recycling endosome |
| CC | IDA | GO:0055037 | recycling endosome |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004012 | phospholipid-translocating ATPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: ATP11A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP11A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3624 | Lung fibrosis |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 6 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD6 | AM-580 | 6 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD484 | Pluripotin | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP11A
CLASSFICATION
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