ATP11A

Summary: The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameATPase phospholipid transporting 11A
OMIM IDMIM:605868
Ensembl IDEnsembl:ENSG00000068650
HGNC IDHGNC:HGNC:13552
PHARMGKB IDPA25101
Map Location13q34

GO terms in ATP11A


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0043312 neutrophil degranulation
BP IBA GO:0045332 phospholipid translocation
BP NAS GO:0045332 phospholipid translocation
BP IBA GO:0048194 Golgi vesicle budding
CC HDA GO:0005765 lysosomal membrane
CC IEA GO:0005769 early endosome
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Gene expression in normal tissue: ATP11A

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 52undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 16UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 2

Gene-drug pathway distribution

undefined19Apoptosis regulation2Terpenoid backbone biosynthesis1Ferroptosis1Biosynthesis of secondary metabolites1Drug metabolism - cytochrome P4501Leukocyte transendothelial migration1One carbon pool by folate1

Pathways in ATP11A


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Database
Pathway ID
Pathway Des.
wikipathways WP3624 Lung fibrosis
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-6798695 Neutrophil degranulation
reactome R-HSA-936837 Ion transport by P-type ATPases
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 6
iGMDRD121 GMX1778 2
iGMDRD77 Itraconazole 3
iGMDRD870 BRD63610 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP11A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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