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TOPBP1

Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
DNA topoisomerase II binding protein 1	MIM:607760	Ensembl:ENSG00000163781	HGNC:HGNC:17008	PA134934073	3q22.1

Gene Categories:

TUMOR SUPPRESSOR DNA REPAIR

GO terms in TOPBP1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0003677	DNA binding
MF	IPI	GO:0005515	protein binding
MF	TAS	GO:0008022	protein C-terminus binding
MF	IPI	GO:0042802	identical protein binding
CC	IEA	GO:0000794	condensed nuclear chromosome
CC	IEA	GO:0000922	spindle pole
CC	IEA	GO:0001673	male germ cell nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005694	chromosome
CC	IEA	GO:0005737	cytoplasm
CC	IEA	GO:0005815	microtubule organizing center
CC	IDA	GO:0015629	actin cytoskeleton
CC	IDA	GO:0016604	nuclear body
CC	IDA	GO:0016605	PML body
BP	TAS	GO:0006259	DNA metabolic process
BP	NAS	GO:0006281	DNA repair
BP	IDA	GO:0006974	cellular response to DNA damage stimulus
BP	IDA	GO:0010212	response to ionizing radiation
BP	IBA	GO:0033314	mitotic DNA replication checkpoint

Gene expression in normal tissue: TOPBP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOPBP1

Database	Pathway ID	Pathway Des.
pid	atr_pathway	ATR signaling pathway
pid	bard1pathway	BARD1 signaling events
pid	e2f_pathway	E2F transcription factor network
pid	fanconi_pathway	Fanconi anemia pathway
kegg	hsa03440	Homologous recombination - Homo sapiens (human)
wikipathways	WP3875	ATR Signaling
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-5633007	Regulation of TP53 Activity
reactome	R-HSA-5685938	HDR through Single Strand Annealing (SSA)
reactome	R-HSA-5685942	HDR through Homologous Recombination (HRR)
reactome	R-HSA-5693532	DNA Double-Strand Break Repair
reactome	R-HSA-5693538	Homology Directed Repair
reactome	R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactome	R-HSA-5693579	Homologous DNA Pairing and Strand Exchange
reactome	R-HSA-5693607	Processing of DNA double-strand break ends
reactome	R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange
reactome	R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation
reactome	R-HSA-69473	G2/M DNA damage checkpoint
reactome	R-HSA-69481	G2/M Checkpoints
reactome	R-HSA-69620	Cell Cycle Checkpoints
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-73894	DNA Repair
reactome	R-HSA-74160	Gene expression (Transcription)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD394	BX-795	2
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD781	Sirolimus	3
iGMDRD248	BRD4354	1
iGMDRD425	ERASTIN	2
iGMDRD60	Quinoclamine	2
iGMDRD353	PD0325901	1
iGMDRD630	ML203	3
iGMDRD414	MST-312	2
iGMDRD399	Selumetinib	2
iGMDRD662	JQ-1	3
iGMDRD329	Merck60	6
iGMDRD398	Sepantronium	2
iGMDRD289	Parthenolide	2
iGMDRD221	Tamoxifen	6
iGMDRD192	CIL56	4
iGMDRD271	Brefeldin A	3
iGMDRD138	PX 12	2
iGMDRD137	Indisulam	2
iGMDRD5	Tyrphostin AG 1478	5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOPBP1

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DATATYPES

CLASSFICATION

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