TOPBP1
Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607760 Ensembl IDEnsembl:ENSG00000163781 HGNC IDHGNC:HGNC:17008 PHARMGKB IDPA134934073 Map Location3q22.1 | |||||
GO terms in TOPBP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008022 | protein C-terminus binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IEA | GO:0000794 | condensed nuclear chromosome |
| CC | IEA | GO:0000922 | spindle pole |
Gene expression in normal tissue: TOPBP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TOPBP1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atr_pathway | ATR signaling pathway |
| pid | bard1pathway | BARD1 signaling events |
| pid | e2f_pathway | E2F transcription factor network |
| pid | fanconi_pathway | Fanconi anemia pathway |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| wikipathways | WP3875 | ATR Signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TOPBP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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