PAX5
Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| paired box 5 | MIM:167414 | Ensembl:ENSG00000196092 | HGNC:HGNC:8619 | PA32959 | 9p13.2 |
GO terms in PAX5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006959 | humoral immune response |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0007568 | aging |
| BP | TAS | GO:0009887 | animal organ morphogenesis |
| BP | IEA | GO:0021670 | lateral ventricle development |
| BP | IEA | GO:0021987 | cerebral cortex development |
| BP | IEA | GO:0030534 | adult behavior |
| BP | IEA | GO:0035914 | skeletal muscle cell differentiation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048701 | embryonic cranial skeleton morphogenesis |
| BP | TAS | GO:0050855 | regulation of B cell receptor signaling pathway |
| BP | IEA | GO:0051573 | negative regulation of histone H3-K9 methylation |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: PAX5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAX5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling |
| pid | cmyb_pathway | C-MYB transcription factor network |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| netpath | Pathway_ID | ID |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP53 | ID signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD672 | Alectinib | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD221 | Tamoxifen | 4 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD311 | Dacinostat | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD353 | PD0325901 | 3 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD792 | Cetuximab | 1 |
| iGMDRD347 | Y-39983 | 1 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD126 | Tipifarnib | 8 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD686 | PF4708671 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD793 | BEC (hydrochloride) | 3 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD375 | GW-405833 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAX5
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.