NCOA3


Summary: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor coactivator 3MIM:601937Ensembl:ENSG00000124151HGNC:HGNC:7670PA3147220q13.12

GO terms in NCOA3


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISSGO:0000993RNA polymerase II core binding
MFIDAGO:0003713transcription coactivator activity
MFIMPGO:0003713transcription coactivator activity
MFNASGO:0003713transcription coactivator activity
MFIDAGO:0004402histone acetyltransferase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016922nuclear receptor binding
MFIPIGO:0016922nuclear receptor binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIBAGO:0035257nuclear hormone receptor binding
MFIDAGO:0035257nuclear hormone receptor binding
MFNASGO:0046966thyroid hormone receptor binding
MFIMPGO:0046982protein heterodimerization activity
MFIPIGO:0047485protein N-terminus binding
MFNASGO:0050681androgen receptor binding
MFIPIGO:0097718disordered domain specific binding
BPIEAGO:0006351transcription, DNA-templated
BPIMPGO:0010628positive regulation of gene expression
BPIEAGO:0016573histone acetylation
BPNASGO:0030521androgen receptor signaling pathway
BPIBAGO:0032870cellular response to hormone stimulus
BPTASGO:0035624receptor transactivation
BPISSGO:0043697cell dedifferentiation
BPIMPGO:0045618positive regulation of keratinocyte differentiation
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0071392cellular response to estradiol stimulus
BPISSGO:1902459positive regulation of stem cell population maintenance
BPISSGO:2000035regulation of stem cell division
BPIMPGO:2001141regulation of RNA biosynthetic process
CCIDAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCIMPGO:0032991protein-containing complex
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: NCOA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NCOA3


DatabasePathway IDPathway Des.
biocartacarm1pathwaytranscription regulation by methyltransferase of carm1
biocartararrxrpathwaynuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2876Pregnane X Receptor pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP437EGF-EGFR Signaling Pathway
pidera_genomic_pathwayValidated nuclear estrogen receptor alpha network
piderb_genomic_pathwayValidated nuclear estrogen receptor beta network
pidhnf3apathwayFOXA1 transcription factor network
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
pharmgkbPA2027Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_EGFR1EGFR1
netpathPathway_IL4IL4

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD670ML 2103
iGMDRD151CHM-13
iGMDRD211(1S,3R)-RSL33
iGMDRD394BX-7951
iGMDRD123Isoevodiamine1
iGMDRD634SCHEMBL26080411
iGMDRD341Triacsin c4
iGMDRD221Tamoxifen1
iGMDRD289Parthenolide1
iGMDRD441TW 371
iGMDRD267Oligomycin A3
iGMDRD187BRD98763
iGMDRD870BRD636101
iGMDRD77Itraconazole6
iGMDRD202Curcumin3
iGMDRD138PX 123
iGMDRD251ML1623
iGMDRD255SB2250023
iGMDRD64Parbendazole1
iGMDRD60Quinoclamine2
iGMDRD369TGX-1153
iGMDRD23Gossypol3
iGMDRD42Vorinostat2
iGMDRD188Piperlongumine1
iGMDRD871BRD63682
iGMDRD872BRD71372
iGMDRD329Merck602
iGMDRD780PP-302

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCOA3

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