NCOA3


Summary: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010].

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OMIM ID
Ensembl ID
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GO terms in NCOA3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISS GO:0000993 RNA polymerase II core binding
MF IDA GO:0003713 transcription coactivator activity
MF IMP GO:0003713 transcription coactivator activity
MF NAS GO:0003713 transcription coactivator activity
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Gene expression in normal tissue: NCOA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined21Chromatin histone acetylation2Biosynthesis of secondary metabolites1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Apoptosis regulation1Ferroptosis1Drug metabolism - cytochrome P4501

Pathways in NCOA3


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Database
Pathway ID
Pathway Des.
biocarta carm1pathway transcription regulation by methyltransferase of carm1
biocarta rarrxrpathway nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1430728 Metabolism
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD670 ML 210 3
iGMDRD151 CHM-1 3
iGMDRD211 (1S,3R)-RSL3 3
iGMDRD394 BX-795 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCOA3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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