NCOA3
Summary: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor coactivator 3 | MIM:601937 | Ensembl:ENSG00000124151 | HGNC:HGNC:7670 | PA31472 | 20q13.12 |
GO terms in NCOA3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISS | GO:0000993 | RNA polymerase II core binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IMP | GO:0003713 | transcription coactivator activity |
| MF | NAS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0004402 | histone acetyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016922 | nuclear receptor binding |
| MF | IPI | GO:0016922 | nuclear receptor binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IBA | GO:0035257 | nuclear hormone receptor binding |
| MF | IDA | GO:0035257 | nuclear hormone receptor binding |
| MF | NAS | GO:0046966 | thyroid hormone receptor binding |
| MF | IMP | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | NAS | GO:0050681 | androgen receptor binding |
| MF | IPI | GO:0097718 | disordered domain specific binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0016573 | histone acetylation |
| BP | NAS | GO:0030521 | androgen receptor signaling pathway |
| BP | IBA | GO:0032870 | cellular response to hormone stimulus |
| BP | TAS | GO:0035624 | receptor transactivation |
| BP | ISS | GO:0043697 | cell dedifferentiation |
| BP | IMP | GO:0045618 | positive regulation of keratinocyte differentiation |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0071392 | cellular response to estradiol stimulus |
| BP | ISS | GO:1902459 | positive regulation of stem cell population maintenance |
| BP | ISS | GO:2000035 | regulation of stem cell division |
| BP | IMP | GO:2001141 | regulation of RNA biosynthetic process |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IMP | GO:0032991 | protein-containing complex |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: NCOA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCOA3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
| biocarta | rarrxrpathway | nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | erb_genomic_pathway | Validated nuclear estrogen receptor beta network |
| pid | hnf3apathway | FOXA1 transcription factor network |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| pharmgkb | PA2027 | Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL4 | IL4 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD670 | ML 210 | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD780 | PP-30 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCOA3
CLASSFICATION
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