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TNF

Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nametumor necrosis factor OMIM IDMIM:191160 Ensembl IDEnsembl:ENSG00000232810 HGNC IDHGNC:HGNC:11892 PHARMGKB IDPA435 Map Location6p21.33

Gene Categories:

SERINE THREONINE KINASE EXTERNAL SIDE OF PLASMA MEMBRANE DRUGGABLE GENOME PROTEIN PHOSPHATASE CELL SURFACE PROTEASE TUMOR SUPPRESSOR KINASE

GO terms in TNF

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0002020	protease binding
MF	IDA	GO:0005125	cytokine activity
MF	IDA	GO:0005164	tumor necrosis factor receptor binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0042802	identical protein binding
MF	IPI	GO:0042802	identical protein binding

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Gene expression in normal tissue: TNF

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNF

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-168256	Immune System
reactome	R-HSA-381340	Transcriptional regulation of white adipocyte differentiation
reactome	R-HSA-449147	Signaling by Interleukins

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD494	Neopeltolide	1
iGMDRD192	CIL56	3
iGMDRD221	Tamoxifen	4
iGMDRD425	ERASTIN	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNF

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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