TFRC

Summary: This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametransferrin receptor
OMIM IDMIM:190010
Ensembl IDEnsembl:ENSG00000072274
HGNC IDHGNC:HGNC:11763
PHARMGKB IDPA36478
Map Location3q29

GO terms in TFRC


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005576 extracellular region
CC HDA GO:0005615 extracellular space
CC IDA GO:0005768 endosome
CC IEA GO:0005769 early endosome
CC TAS GO:0005886 plasma membrane
CC IGI GO:0005887 integral component of plasma membrane
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Gene expression in normal tissue: TFRC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined7MicroRNAs in cancer1Drug metabolism - cytochrome P4501Chromatin histone acetylation1

Pathways in TFRC


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Database
Pathway ID
Pathway Des.
wikipathways WP2007 Iron metabolism in placenta
pid hif1_tfpathway HIF-1-alpha transcription factor network
pid hnf3bpathway FOXA2 and FOXA3 transcription factor networks
pid myc_activpathway Validated targets of C-MYC transcriptional activation
kegg hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
kegg hsa04144 Endocytosis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD483 SCH-529074 3
iGMDRD77 Itraconazole 3
iGMDRD221 Tamoxifen 3
iGMDRD150 RITA 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TFRC

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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