TFRC
Summary: This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transferrin receptor | MIM:190010 | Ensembl:ENSG00000072274 | HGNC:HGNC:11763 | PA36478 | 3q29 |
GO terms in TFRC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005768 | endosome |
| CC | IEA | GO:0005769 | early endosome |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IGI | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005905 | clathrin-coated pit |
| CC | IGI | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0010008 | endosome membrane |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | NAS | GO:0016020 | membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | TAS | GO:0030665 | clathrin-coated vesicle membrane |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | IEA | GO:0042470 | melanosome |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0055037 | recycling endosome |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | HDA | GO:0072562 | blood microparticle |
| CC | HDA | GO:1903561 | extracellular vesicle |
| CC | IDA | GO:1990712 | HFE-transferrin receptor complex |
| BP | IMP | GO:0001558 | regulation of cell growth |
| BP | NAS | GO:0006879 | cellular iron ion homeostasis |
| BP | IEA | GO:0030316 | osteoclast differentiation |
| BP | IDA | GO:0030890 | positive regulation of B cell proliferation |
| BP | IDA | GO:0031623 | receptor internalization |
| BP | IC | GO:0033572 | transferrin transport |
| BP | IDA | GO:0033572 | transferrin transport |
| BP | TAS | GO:0033572 | transferrin transport |
| BP | IDA | GO:0035690 | cellular response to drug |
| BP | IDA | GO:0042102 | positive regulation of T cell proliferation |
| BP | IMP | GO:0042127 | regulation of cell proliferation |
| BP | IEA | GO:0045780 | positive regulation of bone resorption |
| BP | IDA | GO:0045830 | positive regulation of isotype switching |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IDA | GO:0097286 | iron ion import |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | IC | GO:0004998 | transferrin receptor activity |
| MF | IDA | GO:0004998 | transferrin receptor activity |
| MF | NAS | GO:0004998 | transferrin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0033570 | transferrin transmembrane transporter activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: TFRC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TFRC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2007 | Iron metabolism in placenta |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_TCR | TCR |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-432722 | Golgi Associated Vesicle Biogenesis |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-917937 | Iron uptake and transport |
| reactome | R-HSA-917977 | Transferrin endocytosis and recycling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD150 | RITA | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD176 | Decitabine | 1 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD499 | PDMP | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TFRC
CLASSFICATION
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