TFE3
Summary: This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:314310 Ensembl IDEnsembl:ENSG00000068323 HGNC IDHGNC:HGNC:11752 PHARMGKB IDPA36467 Map LocationXp11.23 | |||||
GO terms in TFE3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IMP | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | ISS | GO:0006959 | humoral immune response |
Gene expression in normal tissue: TFE3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TFE3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4241 | Type 2 papillary renal cell carcinoma |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| pid | e2f_pathway | E2F transcription factor network |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TFE3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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