MAP3K2

Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase kinase kinase 2
OMIM IDMIM:609487
Ensembl IDEnsembl:ENSG00000169967
HGNC IDHGNC:HGNC:6854
PHARMGKB IDPA30598
Map Location2q14.3

GO terms in MAP3K2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0000186 activation of MAPKK activity
BP TAS GO:0000187 activation of MAPK activity
BP TAS GO:0006468 protein phosphorylation
BP TAS GO:0007257 activation of JUN kinase activity
BP IBA GO:0007346 regulation of mitotic cell cycle
BP IBA GO:0023014 signal transduction by protein phosphorylation
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Gene expression in normal tissue: MAP3K2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 15undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 29BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 6

Gene-drug pathway distribution

undefined17Genome integrity1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Apoptosis regulation1Drug metabolism - cytochrome P4501

Pathways in MAP3K2


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Database
Pathway ID
Pathway Des.
wikipathways WP195 IL-1 signaling pathway
wikipathways WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP422 MAPK Cascade
wikipathways WP437 EGF-EGFR Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD6 AM-580 2
iGMDRD221 Tamoxifen 6
iGMDRD77 Itraconazole 1
iGMDRD318 PAC-1 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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