MAP3K2
Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 2 | MIM:609487 | Ensembl:ENSG00000169967 | HGNC:HGNC:6854 | PA30598 | 2q14.3 |
GO terms in MAP3K2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007257 | activation of JUN kinase activity |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: MAP3K2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_TNFalpha | TNFalpha |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| biocarta | mapkpathway | mapkinase signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD6 | AM-580 | 2 |
| iGMDRD221 | Tamoxifen | 6 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K2
CLASSFICATION
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