MAP3K2


Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase kinase 2MIM:609487Ensembl:ENSG00000169967HGNC:HGNC:6854PA305982q14.3

GO terms in MAP3K2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000186activation of MAPKK activity
BPTASGO:0000187activation of MAPK activity
BPTASGO:0006468protein phosphorylation
BPTASGO:0007257activation of JUN kinase activity
BPIBAGO:0007346regulation of mitotic cell cycle
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIEPGO:0071260cellular response to mechanical stimulus
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004709MAP kinase kinase kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019901protein kinase binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: MAP3K2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K2


DatabasePathway IDPathway Des.
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP422MAPK Cascade
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
netpathPathway_EGFR1EGFR1
netpathPathway_IL1IL1
netpathPathway_TNFalphaTNFalpha
piderbb1_downstream_pathwayErbB1 downstream signaling
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
biocartamapkpathwaymapkinase signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD6AM-5802
iGMDRD221Tamoxifen6
iGMDRD77Itraconazole1
iGMDRD318PAC-13
iGMDRD202Curcumin3
iGMDRD137Indisulam2
iGMDRD82Quiflapon3
iGMDRD887Compound 23 citrate3
iGMDRD67PENFLURIDOL3
iGMDRD414MST-3125
iGMDRD871BRD63683
iGMDRD144NSC953972
iGMDRD532Olaparib3
iGMDRD307Manumycin A3
iGMDRD772BRD47703
iGMDRD280CYTOCHALASIN B1
iGMDRD132(-)-gallocatechin-3-O-gallate4
iGMDRD341Triacsin c3
iGMDRD61Kinetin riboside3
iGMDRD499PDMP1
iGMDRD316N9-Isopropyl-olomoucine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K2

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