PGR
Summary: This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| progesterone receptor | MIM:607311 | Ensembl:ENSG00000082175 | HGNC:HGNC:8910 | PA266 | 11q22.1 |
GO terms in PGR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | IEA | GO:0004879 | nuclear receptor activity |
| MF | IEA | GO:0005496 | steroid binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0051117 | ATPase binding |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0001542 | ovulation from ovarian follicle |
| BP | IEA | GO:0002070 | epithelial cell maturation |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEP | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0038001 | paracrine signaling |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048286 | lung alveolus development |
| BP | IEA | GO:0050678 | regulation of epithelial cell proliferation |
| BP | IEA | GO:0050847 | progesterone receptor signaling pathway |
| BP | IEA | GO:0060748 | tertiary branching involved in mammary gland duct morphogenesis |
Gene expression in normal tissue: PGR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PGR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP2781 | Signaling by ERBB4 |
| wikipathways | WP34 | Ovarian Infertility Genes |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| pid | anthraxpathway | Cellular roles of Anthrax toxin |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1251985 | Nuclear signaling by ERBB4 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4090294 | SUMOylation of intracellular receptors |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD870 | BRD63610 | 6 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD783 | BRD-K93923542-001-01-9 | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD119 | Temsirolimus | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PGR
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.